Development of transcranial electrical stimulation for intraoperative neuromonitoring
Project/Area Number |
26462248
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Wakayama Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
筒井 俊二 和歌山県立医科大学, 医学部, 講師 (70423960)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | spinal cord monitoring / transcranial stimulation / motor evoked potential / multi train stimulation / spine surgery / transcranial / high frequency / multi-train / electrical stimulation / intraoperative / 脊椎脊髄手術 / 術中運動昨日モニタリング / 大脳刺激筋誘発電位 / 多連発刺激 / 安全性 / 術中運動機能モニタリング |
Outline of Final Research Achievements |
Weinvestigated the safety of highfrequency MTS, behaviorally and histologically. TcMEPs were recorded from the triceps surae muscle in 38 rats. A multipulse stimulus was delivered repeatedly at different rates (2, 5, 10, 20, and 50 Hz), and was defined as MTS. A conditioned taste aversion method was used to investigate the effect of high-frequency MTS on learning and memory function. Subsequently, animals were sacrificed, and the brains were removed and examined using the standard hematoxylin-eosin method. Compared with conventional single train stimulation, TcMEP amplitudes increased 1.3, 2.1, 1.9, and 2.0 times on average with 5, 10, 20, and 50 Hz stimulation, respectively. The aversion index was[0.8 in all animals after they received 100 high-frequency MTSs. Histologically, no pathological changes were evident in the rat brains. High-frequency MTS shows potential to effectively enhance TcMEP responses, and to be used safely in transcranial brain stimulation.
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Report
(5 results)
Research Products
(17 results)
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[Presentation] Improvement of motor evoked potential responses of novel transcranial electrical stimulation technique in intraoperative neurophysiologic monitoring during spinal edeformity surgery: Multi-train stimulation2014
Author(s)
Tsutsui S, Iwasaki H, Yamada H, Hashizume H, Minamide A, Nakagawa Y, Nishi H, Yoshida M
Organizer
Scoliosis Research Society
Place of Presentation
Anchorage, Alaska, USA,
Year and Date
2014-09-10 – 2014-09-13
Related Report
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