Development of diagnostic and predictive tool for motor function decline focusing on sarcopenia and spinal alignment change

• Project/Area Number: 26462249
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Wakayama Medical University
• Principal Investigator: HASHIZUME Hiroshi 和歌山県立医科大学, 医学部, 講師 (10326382)
• Co-Investigator(Kenkyū-buntansha): 岡 敬之 東京大学, 医学部附属病院, 特任准教授 (60401064)
• Research Collaborator: TERAGUCHI Masatoshi ; IWAHASHI Hiroki ; SASAKI Takahide
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 脊椎 / 加齢変性 / 傍脊柱筋 / 大腰筋 / 腰痛 / 矢状面バランス / 一般住民 / MRI / 高齢者 / 矢状面アライメント / 椎体骨折 / 椎間板変性 / spinal alignment / paravertebral muscle / low back pain / sarcopenia / vertebral fracture

Outline of Final Research Achievements

A forward shift of the sagittal vertical axis is reported to be a radiographic predictor of low back pain as well as disability of ADL in elderly. The purpose of this study was to elucidate the association of degenerative changes on MRI and sagittal imbalace in a general population. A total of 794 inhabitants were subjected to a sagittal radiograph of the whole spine in a standing position and whole spine MRI. Cross-sectional area (cm2) and percentage of the fatty degeneration area in the spinal muscles were measured by a DICOM software. Mean cross-sectional areas of the muscles around the lumbar spine were significantly reduced with elevation of age strata in both genders. The fatty degeneration was significantly predominant in the paravertebral muscles in compared to the psoas muscles in both genders. The spinal imbalance was significantly associated with low back pain. Degeneration of the paravertebral muscle at L1 level was a significant associated factor of sagittal imbalance.

Research Products

• [Int'l Joint Research] The University of Hong Kong(Hong Kong)
• [Int'l Joint Research] The University of Hong Kong(Hong Kong)
• [Journal Article] Verification of the sensitivity of functional scores for treatment results - Substantial clinical benefit thresholds for the Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ). (2017)
  • Author(s): Kasai Y, Fukui M, Takahashi K, Ohtori S, Takeuchi D, Hashizume H, Kanamori M, Hosono N, Kanchiku T, Wada E, Sekiguchi M, Konno S, Kawakami M.
  • Journal Title: J Orthop Sci Volume: 印刷中 Issue: 4 Pages: 665-669
  • DOI: 10.1016/j.jos.2017.02.012
  • Peer Reviewed / Open Access
• [Journal Article] The prevalence of tandem spinal stenosis and its characteristics in a population-based MRI study: The Wakayama Spine Study (2017)
  • Author(s): Nagata K, Yoshimura N, Hashizume H, Ishimoto Y, Muraki S, Yamada H, Oka H, Kawaguchi H, Akune T, Tanaka S, Nakamura K, Yoshida M
  • Journal Title: Eur Spine J Volume: in press Issue: 10 Pages: 2529-2535
  • DOI: 10.1007/s00586-017-5072-0
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Serum Levels of Matrix Metalloproteinase-3 and Autoantibodies Related to 2 Rheumatoid Arthritis in the General Japanese Population and their Association with Osteoporosis and Osteoarthritis: The ROAD Study (2017)
  • Author(s): Kodama R, Muraki S, Iidaka T, Oka H, Teraguhi M, Kagotani R, Asai Y, Hashizume H, Yoshida M, Kawaguchi H, Nakamura K, Akune T, Tanaka S, Yoshimura N.
  • Journal Title: J Bone Miner Metab Volume: in press Issue: 2 Pages: 246-253
  • DOI: 10.1007/s00774-017-0834-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Minimally invasive decompression surgery for lumbar spinal stenosis with degenerative scoliosis: Predictive factors of radiographic and clinical outcomes. (2017)
  • Author(s): Minamide A, Yoshida M, Iwahashi H, Simpson AK, Yamada H, Hashizume H, Nakagawa Y, Iwasaki H, Tsutsui S, Kagotani R, Sonekatsu M, Sasaki T, Shinto K, Deguchi T.
  • Journal Title: J Orthop Sci Volume: 印刷中 Issue: 3 Pages: 377-383
  • DOI: 10.1016/j.jos.2016.12.022
  • Peer Reviewed / Open Access
• [Journal Article] Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study. (2017)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Yamada H, Oka H, Minamide A, Nagata K, Ishimoto Y, Kagotani R, Kawaguchi H, Tanaka S, Akune T, Nakamura K, Muraki S, Yoshida M.
  • Journal Title: Osteoarthritis Cartilage Volume: 印刷中 Issue: 7 Pages: 1122-1131
  • DOI: 10.1016/j.joca.2017.01.001
  • NAID: 40021443587
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Association of Lumbar Spondylolisthesis with Low Back Pain and Symptomatic Lumbar Spinal Stenosis in a Population-based Cohort: The Wakayama Spine Study. (2017)
  • Author(s): Ishimoto Y, Yoshimura N, Muraki S, Yamada H, Nagata K, Hashizume H, Takiguchi N, Minamide A, Oka H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine Volume: 印刷中 Issue: 11 Pages: E666-E671
  • DOI: 10.1097/brs.0000000000001960
  • Peer Reviewed
• [Journal Article] Locomotive syndrome is associated with body composition and cardiometabolic disorders in elderly Japanese women. (2016)
  • Author(s): Nakamura M, Kobashi Y, Hashizume H, Oka H, Kono R, Nomura S, Maeno A, Yoshida M, Utsunomiya H.
  • Journal Title: BMC Geriatr Volume: 16 Pages: 166-166
  • Peer Reviewed / Open Access
• [Journal Article] Classification of High Intensity Zones of the Lumbar Spine and Their Association with Other Spinal MRI Phenotypes: The Wakayama Spine Study. (2016)
  • Author(s): Teraguchi M, Samartzis D, Hashizume H, Yamada H, Muraki S, Oka H, Cheung JP, Kagotani R, Iwahashi H, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Cheung KM, Yoshimura N, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 9 Pages: e0160111-e0160111
  • DOI: 10.1371/journal.pone.0160111
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The Association between the Cross-Sectional Area of the Dural Sac and Low Back Pain in a Large Population: The Wakayama Spine Study. (2016)
  • Author(s): Iwahashi H, Yoshimura N, Hashizume H, Yamada H, Oka H, Matsudaira K, Shinto K, Ishimoto Y, Nagata K, Teraguchi M, Kagotani R, Muraki S, Akune T, Tanaka S, Kawaguchi H, Nakamura K, Minamide A, Nakagawa Y, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 8 Pages: e0160002-e0160002
  • DOI: 10.1371/journal.pone.0160002
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Metabolic Syndrome Components Are Associated with Intervertebral Disc Degeneration: The Wakayama Spine Study. (2016)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: PLoS One Volume: 11 Issue: 2 Pages: e0147565-e0147565
  • DOI: 10.1371/journal.pone.0147565
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Radiographic natural course of lumbar degenerative spondylolisthesis and its risk factors related to the progression and onset in a 15-year community-based cohort study: the Miyama study. (2016)
  • Author(s): Enyo Y, Yoshimura N, Yamada H, Hashizume H, Yoshida M.
  • Journal Title: J Orthop Sci. Volume: 20 Issue: 6 Pages: 978-84
  • DOI: 10.1007/s00776-015-0759-8
  • Peer Reviewed
• [Journal Article] Physical Performance Measures Associated With Locomotive Syndrome in Middle-Aged and Older Japanese Women. (2016)
  • Author(s): Nakamura M, Hashizume H, Oka H, Okada M, Takakura R, Hisari A, Yoshida M, Utsunomiya H.
  • Journal Title: J Geriatr Phys Ther. Volume: 38 Issue: 4 Pages: 202-7
  • DOI: 10.1519/jpt.0000000000000033
  • Peer Reviewed
• [Journal Article] The association of combination of disc degeneration, endplate signal change, and Schmorl node with low back pain in a large population study: the Wakayama Spine Study (2015)
  • Author(s): Teraguchi M, Yoshimura N, Hashizume H, Muraki S, Yamada H, Oka H, Minamide A, Nakagawa H, Ishimoto Y, Nagata K, Kagotani R, Tanaka S, Kawaguchi H, Nakamura K, Akune T, Yoshida M.
  • Journal Title: Spine J Volume: 15 Issue: 4 Pages: 622-628
  • DOI: 10.1016/j.spinee.2014.11.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The prevalence of cervical myelopathy among subjects with narrow cervical spinal canal in a population-based MRI study: The Wakayama Spine Study. (2014)
  • Author(s): 52. Nagata K, Yoshimura N, Hashizume H, Muraki S, Ishimoto Y, Yamada H, Takiguchi N, Nakagawa Y, Minamide A, Oka H, Kawaguchi H, Nakamura K, Akune T, Yoshida M
  • Journal Title: Spine J Volume: in press Issue: 12 Pages: 2811-2817
  • DOI: 10.1016/j.spinee.2014.03.051
  • Peer Reviewed / Open Access
• [Presentation] シンポジウム3 一般住民検診からみた脊椎脊髄疾患の評価と応用. 一般住民における脊柱周囲筋群の評価と応用 ―The Wakayama Spine Study． (2017)
  • Author(s): 橋爪 洋、吉村典子、佐々木貴英、岩橋弘樹、岡 敬之、西村行秀、村木重之、松平 浩、山田 宏、吉田宗人．
  • Organizer: 第46回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 札幌市
  • Year and Date: 2017-04-13
  • Invited
• [Presentation] 高齢者の姿勢不良・腰痛に対する椎体骨折と椎間板変性の高位別影響度合いについて-The Wakayama Spine Study (2016)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、寺口真年、岩橋弘樹、浅井宣樹、佐々木貴英、村木重之、松平 浩、筒井俊二、岩﨑 博、南出晃人、中川幸洋、吉田宗人．
  • Organizer: 第24回日本腰痛学会
  • Place of Presentation: 甲府市
  • Year and Date: 2016-09-02
• [Presentation] 傍脊柱筋変性は脊柱バランス不良の最大関連要因である：The Wakayama Spine Study． (2016)
  • Author(s): 橋爪洋、吉村典子、村木重之、松平浩、阿久根徹、中村耕三、吉田宗人．
  • Organizer: 第53回日本リハビリテーション医学会学術集会
  • Place of Presentation: 京都市
  • Year and Date: 2016-06-09
• [Presentation] Aging change of the paravertebral muscles and psoas muscles of the lumbar spine and relation to the low back pain in a general population -The Wakayama Spine Study. (2016)
  • Author(s): Hiroshi Hashizume, Hiroshi Yamada, Hiroyuki Oka, Masatoshi Teraguchi, Hiroki Iwahashi, Takahide Sasaki, Kazunori Shinto, Shigeyuki Muraki, Ko Matsudaira, Akihito Minamide, Yukihiro Nakagawa, Noriko Yoshimura and Munehito Yoshida.
  • Organizer: Asia Pacific Spine Society at Spine Week 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-16
  • Int'l Joint Research
• [Presentation] Paravertebral muscle degeneration is the most significant factor associated with sagittal imbalance: The Wakayama Spine Study. (2016)
  • Author(s): Hiroshi Hashizume, Noriko Yoshimura, Hiroshi Yamada, Hiroyuki Oka, Masatoshi Teraguchi, Hiroki Iwahashi, Yoshiki Asai, Takahide sasaki, Shigeyuki Muraki, Ko Matsudaira, Shunji Tsutsui, Akihito Minamide, Yukihiro Nakagawa, Hiroshi Iwasaki, Munehito Yoshida.
  • Organizer: The International Society for the Study of the Lumbar Spine at Spine Week 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-16
  • Int'l Joint Research
• [Presentation] Diabetes mellitus is a significant risk factor for lumbar disc degeneration in a longitudinal population - based cohort: The Wakayama Spine Study. (2016)
  • Author(s): Masatoshi Teraguchi, Hiroshi Hashizume, Noriko Yoshimura, Shigeyuki Muraki, Hiroshi Yamada, Hiroyuki Oka, Akihito Minamide, Keiji Nagata, Yuyu Ishimoto, Ryohei Kagotani, Munehito Yoshida.
  • Organizer: The International Society for the Study of the Lumbar Spine at Spine Week 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-16
  • Int'l Joint Research
• [Presentation] The association between the cross-sectional area of the dural sac and low back pain in a large population: The Wakayama Spine Study. (2016)
  • Author(s): Hiroki Iwahashi, Noriko Yoshimura, Hiroshi Hashizume, Hiroshi Yamada, Hiroyuki Oka, Munehito Yoshida.
  • Organizer: The International Society for the Study of the Lumbar Spine at Spine Week 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-16
  • Int'l Joint Research
• [Presentation] Novel classification and risk factors of high intensity zone of the lumbar spine: The Wakayama spine study. (2016)
  • Author(s): Masatoshi Teraguchi, Dino Samartzis, Hiroshi Hashizume, Hiroshi Yamada, Shigeyuki Muraki, Hiroyuki Oka, Jason PY Cheung, Noriko Yoshimura, Kenneth MC Cheung, Munehito Yoshida.
  • Organizer: The International Society for the Study of the Lumbar Spine at Spine Week 2016
  • Place of Presentation: シンガポール
  • Year and Date: 2016-05-16
  • Int'l Joint Research
• [Presentation] ロコモ予防体操ビデオを用いた地域住民への介入効果の検証． (2016)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、岩橋弘樹、佐々木貴英、神藤一紀、宮崎展行、中川幸洋、南出晃人、吉田宗人．
  • Organizer: 第89回日本整形外科学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2016-05-12
• [Presentation] シンポジウム1「非特異的腰痛の基礎と臨床」腰椎単純MRI上の加齢変性所見は腰痛の原因か？：The Wakayama Spine Study. (2016)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、寺口真年、岩橋弘樹、佐々木貴英、村木重之、松平 浩、阿久根徹、川口浩、中村耕三、南出晃人、中川幸洋、吉田宗人．
  • Organizer: 第45回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2016-04-14
• [Presentation] シンポジウム3「脊椎矢状面アライメントの異常とその矯正」傍脊柱筋変性は脊柱バランス不良の最大関連要因である：The Wakayama Spine Study. (2016)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、寺口真年、岩橋弘樹、浅井宣樹、佐々木貴英、村木重之、松平 浩、籠谷良平、筒井俊二、岩﨑 博、南出晃人、中川幸洋、吉田宗人．
  • Organizer: 第45回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2016-04-14
• [Presentation] 腰椎単純MRIは腰痛の原因をどこまで説明可能か？：The Wakayama Spine Study． (2015)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、寺口真年、岩橋弘樹、佐々木貴英、村木重之、阿久根徹、川口浩、中村耕三、南出晃人、中川幸洋、田中栄、吉田宗人.
  • Organizer: 第23回日本腰痛学会
  • Place of Presentation: 東京
  • Year and Date: 2015-11-14
  • Invited
• [Presentation] 脊椎加変性疾患の疫学指標ならびに運動機能との関連 ：The Wakayama Spine Study． (2015)
  • Author(s): 橋爪洋、吉村典子、山田宏、吉田宗人．
  • Organizer: 第70回日本体力医学会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-18
  • Invited
• [Presentation] Radiographic changes in the paravertebral muscles of the lumbar spine associated with the C7 sagittal vertical axis: The Wakayama Spine Study (2015)
  • Author(s): Hiroshi Hashizume, Noriko Yoshimura, Hiroshi Yamada, Hirioyuki Oka, Masatoshi Teraguchi, Hiroki Iwahashi, Yoshiki Asai, Hiroshi Iwasaki, Shunji Tsutsui, Takahide Sasaki, Kazunori Shinto, Shigeyuki Muraki, Akihito Minamide, Yukihiro Nakagawa, Munehito Yoshida
  • Organizer: Spine Across the Sea 2015
  • Place of Presentation: ハワイ（アメリカ）
  • Year and Date: 2015-07-26 – 2015-07-30
• [Presentation] Relationship between age-related changes in the paravertebral and psoas muscles of the lumbar spine and low back pain: The Wakayama Spine Study (2015)
  • Author(s): Hiroshi Hashizume, Noriko Yoshimura, Hiroshi Yamada, Hirioyuki Oka, Hiroki Iwahashi, Takahide Sasaki, Masatoshi Teraguchi, Yuyu Ishimoto, Keiji Nagata, Ryohei Kagotani, Shigeyuki Muraki, Akihito Minamide, Yukihiro Nakagawa, Munehito Yoshida
  • Organizer: Spine Across the Sea 2015
  • Place of Presentation: ハワイ（アメリカ）
  • Year and Date: 2015-07-26 – 2015-07-30
• [Presentation] Relationship between age-related changes in the paravertebral and psoas muscles of the lumbar spine and low back pain: The Wakayama Spine Study (2015)
  • Author(s): Hiroshi Hashizume, Noriko Yoshimura, Hiroshi Yamada, Hirioyuki Oka, Hiroki Iwahashi, Takahide Sasaki, Yuyu Ishimoto, Keiji Nagata, Masatoshi Teraguchi, Ryohei Kagotani, Shigeyuki Muraki, Akihito Minamide, Yukihiro Nakagawa, Munehito Yoshida
  • Organizer: 42nd ISSLS Annual Meeting
  • Place of Presentation: サンフランシスコ（アメリカ）
  • Year and Date: 2015-06-08 – 2015-06-12
• [Presentation] Radiographic changes in the paravertebral muscles of the lumbar spine associated with the C7 sagittal vertical axis: The Wakayama Spine Study (2015)
  • Author(s): Hiroshi Hashizume, Noriko Yoshimura, Hiroshi Yamada, Hirioyuki Oka, Hiroki Iwahashi, Yoshiki Asai, Shunji Tsutsui, Takahide Sasaki, Masatoshi Teraguchi, Ryohei Kagotani, Shigeyuki Muraki, Akihito Minamide, Yukihiro Nakagawa, Munehito Yoshida
  • Organizer: 42nd ISSLS Annual Meeting
  • Place of Presentation: サンフランシスコ（アメリカ）
  • Year and Date: 2015-06-08 – 2015-06-12
• [Presentation] Radiographic changes in the paravertebral muscles of the lumbar spine associated with the C7 sagittal vertical axis: The Wakayama Spine Study (2015)
  • Author(s): Hashizume H, Yoshimura N, Teraguchi M, Yoshida M
  • Organizer: Hong Kong 2015 - the Combined Congress of APSS, APPOS & HKIOF
  • Place of Presentation: 香港（中国）
  • Year and Date: 2015-06-05 – 2015-06-07
• [Presentation] ロコモティブシンドロームと腰痛、膝痛、身体能力との関連 (2015)
  • Author(s): 橋爪 洋、山田 宏、吉村典子、岡 敬之、石元優々、長田圭司、寺口真年、籠谷良平、浅井宣樹、宮崎展行、吉田宗人
  • Organizer: 第88回日本整形外科学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2015-05-21 – 2015-05-24
• [Presentation] 腰椎部傍脊柱筋と腸腰筋の性別・年代別分布と腰痛との関連―The Wakayama Spine Study (2015)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、岩橋弘樹、佐々木貴英、石元優々、長田圭司、寺口真年、籠谷良平、浅井宣樹、曽根勝真弓、神藤一紀、出口剛士、村木重之、阿久根徹、田中栄、川口浩、中村耕三、南出晃人、中川幸洋、吉田宗人
  • Organizer: 第44回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-04-16 – 2015-04-18
• [Presentation] 一般住民における腰椎部傍脊柱筋変性と脊柱矢状面バランスの関係―The Wakayama Spine Study (2015)
  • Author(s): 橋爪洋、吉村典子、山田宏、岡敬之、岩橋弘樹、佐々木貴英、石元優々、長田圭司、寺口真年、籠谷良平、筒井俊二、浅井宣樹、曽根勝真弓、神藤一紀、出口剛士、村木重之、阿久根徹、田中栄、川口浩、中村耕三、南出晃人、中川幸洋、吉田宗人
  • Organizer: 第44回日本脊椎脊髄病学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2015-04-16 – 2015-04-18