| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Although the mechanism of intervertebral disc degeneration by inflammatory cytokines has been reported so far, the results showed that pathway mediated by TNF-α-PGE2 / EP receptor activates Wnt signal and induces intervertebral disc cell differentiation . These signals are important transcription signals involved in induction of inflammation and it was considered possible to act as a molecular switch of Wnt signal in intervertebral disc cells. In the future, if activation of Wnt signal by TNFα-PGE 2 signal could be suppressed at the receptor site, it could be possible to lead to a new molecular targeted therapeutic agent in disc degeneration.
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