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The mechanism of descending pain excitatory system in the spinal dorsal horn neurons due to the activation of anterior cingulate cortex

Research Project

Project/Area Number 26462253
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionWakayama Medical University (2015-2016)
Kansai University of Health Sciences (2014)

Principal Investigator

Taniguchi Wataru  和歌山県立医科大学, 医学部, 助教 (20453194)

Co-Investigator(Kenkyū-buntansha) 中塚 映政  関西医療大学, 保健医療学部, 客員教授 (30380752)
Research Collaborator Nishio Naoko  和歌山県立医科大学, 医学部, 特別研究員 (40648359)
Yamanaka Manabu  和歌山県立医科大学, 医学部, 博士研究員 (30597084)
Sonekatsu Mayumi  和歌山県立医科大学, 医学部, 博士研究員 (40725579)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords前帯状皮質 / 前帯状回 / ACC / in vivo パッチクランプ法 / 下行性疼痛賦活 / spinal cord / dorsal horn / EPSC / evoked EPSC
Outline of Final Research Achievements

In this study, we showed the enhancement of spontaneous excitatory postsynaptic currents (sEPSCs) in the spinal dorsal horn neurons of normal rats according to the electrical stimulation of their ACC by using in vivo patch-clamp methods. Howover, we could not find this enhancement in the nerve injury model rats (spared nerve injury rats) because their sEPSCs already had been enhanced before ACC electrical stimulation. Moreover, we confirmed that the enhancement of sEPSCs in SNI rats was inhibited by the injection of a selective AMPA antagonist into ACC. We showed that the electrical stimulation of ACC produced direct excitatory effects in the spinal dorsal horn neurons of normal rats to both noxious and innocuous stimuli to the skin. These results suggest that the descending pain excitatory system could be from anterior cingulate cortex to the spinal dorsal horn neurons.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (14 results)

All 2016 2014 Other

All Int'l Joint Research (2 results) Journal Article (1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results) Book (7 results)

  • [Int'l Joint Research] Department of Physiology/Faculty of Medicine/University of Toronto(カナダ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Department of Physiology/Faculty of Medicine/University of Toronto(カナダ)

    • Related Report
      2015 Research-status Report
  • [Journal Article] TRPV1 channels induce Knee osteoarthritis pain: in vivo patch-clamp analysis2014

    • Author(s)
      Taniguchi W, Nishio N, Yamanaka M, Kiyoyuki Y, Sonekatsu M, Yoshida M, Nakatsuka T
    • Journal Title

      Pain Research

      Volume: 29 Pages: 171-179

    • NAID

      130004692192

    • Related Report
      2014 Research-status Report
  • [Presentation] 神経障害性疼痛における前帯状皮質活性化が脊髄後角ニューロンに与える影響2016

    • Author(s)
      谷口亘, 杉村弥恵, 曽根勝真弓, 西尾尚子, 筒井俊二, 西秀人, 吉田宗人, 中塚映政
    • Organizer
      第38回日本疼痛学会
    • Place of Presentation
      札幌
    • Year and Date
      2016-06-24
    • Related Report
      2016 Annual Research Report
  • [Presentation] In Vivo Patch-clamp Analysis Of Descending Facilitation Of Excitatory Transmission In The Spinal Dorsal Horn By The Anterior Cingulate Cortex Activation.2016

    • Author(s)
      Taniguchi W, Yamanaka M, Sonekatsu M, Nishio N, Tsutsui S, Nishi H, Hashizume H, Yamada H, Nakatsuka T, Yoshida M.
    • Organizer
      Orthopedic Research Society 2016 Annual meeting
    • Place of Presentation
      Orlando, Florida
    • Year and Date
      2016-03-01
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 前帯状皮質から脊髄後角に至る経路は下行性疼痛賦活系を形成する2014

    • Author(s)
      谷口亘, 山中学, 曽根勝真弓, 阿部唯一, 峰巨, 筒井俊二, 橋爪洋, 山田宏, 中塚映政, 吉田宗人
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 情動中枢前帯状皮質の活性化は脊髄後角で直接痛みを増強する.2014

    • Author(s)
      谷口亘, 山中学, 西尾尚子, 曽根勝真弓, 阿部唯一, 峰巨, 筒井俊二, 橋爪洋, 山田宏, 中塚映政, 吉田宗人
    • Organizer
      第43回日本脊椎脊髄病学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-04-17
    • Related Report
      2014 Research-status Report
  • [Book] 特集“痛みとかゆみ” 【痛み・かゆみの科学】 3.痛みの神経伝達機序 JOHNS 32(5)2016

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      4
    • Publisher
      東京医学社
    • Related Report
      2016 Annual Research Report
  • [Book] 最新医学 71(2) 痛みのClinical Neuroscience 8 脊髄機能変化と痛み:アロディニアなどのメカニズムを巡って.2016

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      4
    • Publisher
      最新医学社
    • Related Report
      2015 Research-status Report
  • [Book] Chaptor31. Spinal synaptic plasticity in chronic pain. Neuroprotection and Regeneration of the Spinal Cord.2014

    • Author(s)
      Wataru Taniguchi, Terumasa Nakatsuka
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2014 Research-status Report
  • [Book] 痛みのScience &Practice シリーズ6「痛み診療キーポイント」基礎編A.基礎知識12.痛みの研究手法-パッチクランプ法2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 痛みのScience &Practice シリーズ6「痛み診療キーポイント」基礎編C.脊髄 1.脊髄後角2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 痛みのScience &Practice シリーズ6「痛み診療キーポイント」基礎編D.脳 2.神経可塑性2014

    • Author(s)
      谷口亘, 中塚映政.
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report
  • [Book] 痛みのScience &Practice シリーズ6「痛み診療キーポイント」 基礎編D.脳 3.中枢性感作2014

    • Author(s)
      谷口亘, 中塚映政
    • Total Pages
      1
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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