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Conditional deletion of hedgehog signaling attenuates intervertebral disc degeneration and osteophyte formation

Research Project

Project/Area Number 26462254
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

Nakamura Eiichiro  産業医科大学, 医学部, 准教授 (10412644)

Co-Investigator(Renkei-kenkyūsha) SABANAI Ken  産業医科大学, 医学部, 助教 (70644863)
YAMANE Hirotoshi  産業医科大学, 医学部, 助教 (50721693)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords骨・軟骨代謝学 / 椎間板 / 骨棘 / 脊椎変性 / Hedgehog / Smoothened / Cre / 椎間板変性 / hedgehog / Hedghog
Outline of Final Research Achievements

In this study, we investigate whether the deletion of smoothened (Smo), a key component of the hedgehog pathway in the process of endochondral ossification and intervertebral disc development, attenuates intervertebral disc degeneration and osteophyte formation in the mouse degenerative spine model. Control mice showed severe intervertebral disc degeneration, hypertrophic changes of chondrocytes in the vertebral end plate cartilage and osteophyte formation in the corner of vertebra, whereas, all these phenomena were impaired in the mice with conditional deficient of Smo, indicating that hedgehog signaling has a crucial role in the degenerative spondylosis of the spine.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2014

All Presentation (2 results)

  • [Presentation] Smoothendコンディショナルノックアウトマウスを用いた変形性関節症における骨棘形成過程の解明2014

    • Author(s)
      高田真一朗、中村英一郎、佐羽内 研、大友 一、加納深吉、塚本学、村井哲平、酒井昭典
    • Organizer
      第32回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-07-24 – 2014-07-26
    • Related Report
      2014 Research-status Report
  • [Presentation] The role of smoothened for the osteophyte formation in mouse osteoarthritis.2014

    • Author(s)
      Takada S, Nakamura E, Sabanai K, Otomo H, Sakai A
    • Organizer
      Osteoarthritis Research Society International (OARSI) 2014
    • Place of Presentation
      The Center of New Industries and Technologies Paris, France
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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