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Pathophysiological effects of lumbar instrumentation surgery on lumbosacral nerve roots in the vertebral foramen

Research Project

Project/Area Number 26462255
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionJapan Organization of Occupational Health and Safety, Spinal Injuries Center

Principal Investigator

MORISHITA YUICHIROU  独立行政法人労働者健康安全機構総合せき損センター(研究部), 独立行政法人労働者健康安全機構総合せき損センター(研究部), 研究員(移行) (20648555)

Co-Investigator(Kenkyū-buntansha) 芝 啓一郎  独立行政法人労働者健康安全機構総合せき損センター(研究部), その他部局等, 研究員(移行) (90574137)
Co-Investigator(Renkei-kenkyūsha) MAEDA TAKESHI  独立行政法人労働者健康安全機構, 総合せき損センター(研究部), 研究員 (80315077)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords腰椎変形すべり症 / 腰椎後方固定術 / 腰椎椎間孔 / 腰椎椎間孔内圧 / 腰椎変性すべり症 / 腰椎変性辷り症 / 腰髄神経根 / 腰椎後方固定
Outline of Final Research Achievements

The local pressure of the L4-5 vertebral foramen increased significantly during lumbar spine extension compared to that in the neutral position, although these values were almost identical after L4-5 internal fixation. While, the local pressure of the L5-S vertebral foramen both before and after L4-5 internal fixation increased significantly during lumbar spine extension compared to the neutral position.
Our results suggested that the nerve roots in fixed segments might be exposed to lesser external dynamic stresses with lumbar spine motion, while those in segments caudal to the fixed segments may be exposed to higher external dynamic stresses after lumbar instrumentation surgery.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (9 results)

All 2017 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (4 results)

  • [Journal Article] Morphologic evaluation of lumbosacral nerve roots in the vertebral foramen: Measurement of local pressure of the intervertebral foramen.2017

    • Author(s)
      Yuichiro Morishita, et al
    • Journal Title

      Clinical Spine Surgery

      Volume: 印刷中 Issue: 6 Pages: E839-E844

    • DOI

      10.1097/bsd.0000000000000433

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiological outcome of short segment posterior instrumentation and fusion for thoracolumbar burst fractures.2015

    • Author(s)
      Vu TT, Morishita Y, et al
    • Journal Title

      Asian Spine J.

      Volume: 9(3) Issue: 3 Pages: 427-32

    • DOI

      10.4184/asj.2015.9.3.427

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diastematomyelia: a surgical case with long-term follow-up.2015

    • Author(s)
      Bekki H, Morishita Y, et al.
    • Journal Title

      Asian Spine J.

      Volume: 9(1) Issue: 1 Pages: 99-102

    • DOI

      10.4184/asj.2015.9.1.99

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid progressive clinical deterioration of cervical spondylotic myelopathy.2015

    • Author(s)
      Morishita Y, et al.
    • Journal Title

      Spinal Cord

      Volume: 53(5) Issue: 5 Pages: 408-12

    • DOI

      10.1038/sc.2014.137

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pathophysiological effects of lumbar instrumentation surgery on lumbosacral nerve roots in the vertebral foramen2014

    • Author(s)
      Morishita Y, Maeda T, Ueta T, Naito M, Shiba K.
    • Journal Title

      SPINE

      Volume: 39

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 腰椎椎間孔内における腰髄神経根の生理学的病態についての検討:Instrumentation Surgeryによる神経根への外的影響2016

    • Author(s)
      森下雄一郎
    • Organizer
      日本脊椎インストゥルメント学会
    • Place of Presentation
      長崎
    • Year and Date
      2016-10-29
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腰椎椎間孔内における腰髄神経根の生理学的病態についての検討2015

    • Author(s)
      森下雄一郎、前田健、森英治、弓削至、河野修、高尾恒彰、坂井宏旭、益田宗彰、林哲生、松下昌史、植田尊善、芝啓一郎
    • Organizer
      第44回日本脊椎脊髄病学会
    • Place of Presentation
      福岡市 福岡国際会議場
    • Year and Date
      2015-04-18
    • Related Report
      2015 Research-status Report
  • [Presentation] 腰椎変性疾患に対するInstrumentation Surgery :腰仙髄神経根の腰椎椎間孔内における生理学的病態2014

    • Author(s)
      森下雄一郎、前田 健、植田 尊善、芝 啓一郎
    • Organizer
      第49回日本脊髄障害医学会
    • Place of Presentation
      旭川グランドホテル(北海道旭川市)
    • Year and Date
      2014-09-11 – 2014-09-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 腰椎変性疾患に対するInstrumentation Surgery -術中椎弓根スクリューによる神経根障害についての検討-2014

    • Author(s)
      森下雄一郎、前田 健、植田 尊善、芝 啓一郎
    • Organizer
      第43回日本脊椎脊髄病学会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-04-18
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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