Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
We successfully developed novel osteochondral repair model by using young C57Bl/6 mice(Matsuoka M, Onodera T et al., Tissue Eng. 2015)。This novel animal model made us to clarify the cartilage repair mechanisms in glycosphingolipid depletion mice(Matsuoka M, Onodera T et al., Sci Rep. 2017)。In addition, we applied this animal model to Syndecan-4 knockout mice. Surprisingly, osteochondral repair in Syndecan-4 knockout mice is enhanced compare with wildtype mice.
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