Functional role of Syndecan-4 in the process of osteochondral repair

• Project/Area Number: 26462257
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Orthopaedic surgery
• Research Institution: Hokkaido University
• Principal Investigator: ONODERA TOMOHORO 北海道大学, 大学病院, 講師 (70547174)
• Co-Investigator(Kenkyū-buntansha): 岩崎 倫政 北海道大学, 医学研究科, 教授 (30322803)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 整形外科 / 軟骨損傷 / 軟骨再生 / 骨軟骨修復 / 動物モデル / 軟骨修復 / シンデカン４

Outline of Final Research Achievements

We successfully developed novel osteochondral repair model by using young C57Bl/6 mice（Matsuoka M, Onodera T et al., Tissue Eng. 2015）。This novel animal model made us to clarify the cartilage repair mechanisms in glycosphingolipid depletion mice（Matsuoka M, Onodera T et al., Sci Rep. 2017）。In addition, we applied this animal model to Syndecan-4 knockout mice. Surprisingly, osteochondral repair in Syndecan-4 knockout mice is enhanced compare with wildtype mice.

Research Products

• [Journal Article] Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice (2017)
  • Author(s): Matsuoka Masatake, Onodera Tomohiro, Homan Kentarou, Sasazawa Fumio, Furukawa Junichi, Momma Daisuke, Baba Rikiya, Hontani Kazutoshi, Joutoku Zenta, Matsubara Shinji, Yamashita Tadashi, Iwasaki Norimasa.
  • Journal Title: Scientific Reports Volume: 7 Issue: 1 Pages: 43729-43729
  • DOI: 10.1038/srep43729
  • NAID: 120006219943
  • Peer Reviewed / Open Access
• [Journal Article] An Articular Cartilage Repair Model in Common C57Bl/6 Mice. (2015)
  • Author(s): Matsuoka Masatake, Onodera Tomohiro, Sasazawa Fumio, Momma Daisuke, Baba Rikiya, Hontani Kazutoshi, Iwasaki Norimasa
  • Journal Title: Tissue Engineering Part C Methods Volume: ‐ Issue: 8 Pages: 767-72
  • DOI: 10.1089/ten.tec.2014.0440
  • Peer Reviewed
• [Presentation] Depletion of Gangliosides Enhanced Articular Cartilage Repair by Suppressing the Chondrocyte hypertrophy Surrounding Repair Tissue (2017)
  • Author(s): Matsuoka Masatake
  • Organizer: Orthopaedic Research Society Annual meeting
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2017-03-19
  • Int'l Joint Research
• [Presentation] 汎用性の高いC５７Bl/6マウスにおける軟骨全層欠損モデルの確立 (2014)
  • Author(s): 松岡正剛、小野寺智洋、笹沢史生、門間太輔、馬場力哉、本谷和俊、岩崎倫政
  • Organizer: 日本整形外科学会基礎学術集会（第29回）
  • Place of Presentation: 城山観光ホテル（鹿児島市）
  • Year and Date: 2014-10-09 – 2014-10-10