Image-guided cryoablation for palliative therapy of skeletal metastases.
Project/Area Number |
26462260
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Orthopaedic surgery
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Research Institution | Aichi Cancer Center Research Institute (2015-2017) Nagoya University (2014) |
Principal Investigator |
Tsukushi Satoshi 愛知県がんセンター(研究所), 腫瘍免疫学部, 研究員 (90378109)
|
Co-Investigator(Kenkyū-buntansha) |
西田 佳弘 名古屋大学, 医学系研究科, 准教授 (50332698)
浦川 浩 名古屋大学, 医学部附属病院, 病院講師 (60584753)
小澤 英史 名古屋大学, 医学部附属病院, 病院助教 (60635572)
新井 英介 名古屋大学, 医学部附属病院, 医員 (40612841)
生田 国大 名古屋大学, 医学部附属病院, 医員 (40732657)
|
Research Collaborator |
YOSHIDA Masahiro
HAYASHI Takuma
HASEGAWA Hiroaki
SUZUKI Syuichiro
|
Project Period (FY) |
2014-04-01 – 2018-03-31
|
Project Status |
Completed (Fiscal Year 2017)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | 肉腫 / 組織学的浸潤 / 切除縁 / 広範切除術 / 癌 / 転移性骨腫瘍 / 凍結療法 |
Outline of Final Research Achievements |
The aim of this study was to investigate local control of in non-small round cell soft tissue sarcomas.The overall survival rates at 5 years were 85.7%.The local recurrence-free survival rates at 5 years were 89.8% (positive margin: 72.5%, margin of 2 mm or less: 60.6%). In the univariate analysis size, depth, histological grade and positive margin were significant unfavorable prognostic factors for local recurrence free survival. In multivariate analyses, we showed that positive margin and histological grade were significant independent predictors of local recurrence free survival.Positive margin and histological grade were important prognostic factors for local recurrence. Close margin (2 mm or less) in the longitudinal direction was associated with a high risk of local recurrence.The reach of the local treatment should be decided based on these factors.
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Report
(5 results)
Research Products
(43 results)
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[Journal Article] Y.Analysis of Factors for Predicting Survival in Soft-tissue Sarcoma with Metastatic Disease at Initial Presentation2017
Author(s)
Nakamura T, Katagiri H, Shido Y, Hamada S, Yamada K, Nagano A, Yamada S, Tsukushi S, Ishimura D, Matsumine A, Sudo A, Nishida
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Journal Title
Anticancer Res.
Volume: 37
Pages: 3137-3141
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[Journal Article] Oncological outcome after lung metastasis in patients presenting with localized chondrosarcoma at extremities: Tokai Musculoskeletal Oncology Consortium study.2016
Author(s)
Nakamura T, Matsumine A, Yamada S, Tsukushi S, Kawanami K, Ohno T, Katagiri H, Sugiura H, Yamada K, Yamada Y, Sudo A, Nishida Y
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Journal Title
Onco Targets Ther
Volume: 9
Pages: 4747-51
DOI
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Peer Reviewed
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[Presentation] 進行性平滑筋肉腫の臨床的特徴2018
Author(s)
小澤英史,吉田雅博,林卓馬,安藤正志,水野美香,室圭,清水泰博,谷田部恭,小森康司,本多和典,筑紫聡
Organizer
第1回サルコーマ治療研究学会学術集会
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[Presentation] 骨・軟部腫瘍における機能評価法2017
Author(s)
小倉浩一,上原浩介,秋山達,岩田慎太郎,原田裕介,筑紫聡,小林英介,丹澤義一,遠藤誠,中谷文彦,中馬広一
Organizer
第90回日本整形外科学会学術集会
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[Presentation] C-reactive proteinは初診時遠隔転移を有する軟部肉腫症例における予後不良因子である-東海骨軟部腫瘍コンソーシアム共同研究2017
Author(s)
中村知樹,片桐浩久,紫藤洋二,山田健志,濵田俊介,松峯昭彦,須藤啓広,山田聡,筑紫聡,永野昭仁,石村大輔,西田佳弘
Organizer
第50回日本整形外科学会骨軟部腫瘍学術集会
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