| Project/Area Number |
26462269
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
越智 光夫 広島大学, その他部局等, 学長 (70177244)
近江 雅人 大阪大学, 医学系研究科, 教授 (60273645)
安達 伸生 広島大学, 医歯薬保健学研究院(医), 教授 (30294383)
味八木 茂 広島大学, 病院(医), 講師 (10392490)
中佐 智幸 広島大学, 病院(医), 病院助教 (60467769)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 光干渉断層法 / 軟骨組織 / 定量評価 / 離断性骨軟骨炎 / 光診断 |
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| Outline of Final Research Achievements |
Samples from atelocollagen embedded chondrocytes and mouse knee osteoarthritis (OA) model were harvested and images were obtained by optical coherence tomography (OCT) system. Obtained images and their OCT values were evaluated quantitatively by originally developed software. Using our method, OCT could demonstrate articular cartilage matrix deposition in the sample of atelocollagen with chondrocytes comparing with histological evaluation. From the animal study, it was demonstrated that femur articular cartilage in mouse OA model presented significantly lower OCT value compared to normal articular cartilage.
These our data show the great potential of OCT system in orthopaedic field for quantitative evaluation of articular cartilage with noncontact manner. Moreover, the OCT probe system that enable real-time optical biopsy will be helpful to diagnose articular cartilage pathology quantitatively in clinical practice.
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