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Transplantation of human adipose tissue-derived regenerative cells for peripheral nerve regeneration.

Research Project

Project/Area Number 26462270
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionHiroshima University

Principal Investigator

YOKOTA Kazunori  広島大学, 病院(医), 教授 (20403529)

Co-Investigator(Kenkyū-buntansha) 越智 光夫  広島大学, その他部局等, 学長 (70177244)
亀井 直輔  広島大学, 病院(医), 講師 (70444685)
宮本 純平  広島大学, 病院(医), 病院助教 (90365312)
Co-Investigator(Renkei-kenkyūsha) HIGASHI YUKIHITO  広島大学, 原爆放射線医科学研究所, 教授 (40346490)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords筋・神経病学 / 運動器外傷学 / 再生医学
Outline of Final Research Achievements

In the histologic evaluation by the toluidine blue and anti S-100 antibody staining, there were more nerve regeneration in ADRC tlansplantation group. However, by the functional evaluation of the exercise-induced EMG and walk analysis, the meaningful difference between each group were not recognized. The effect of the amyotrophy prevention was expected with porting ADRC to a skeletal muscle as well as nerve defect.
Because of the ADRC signal disappearance in in vivo imaging and of few human derived cells in immunostaining, it was difficult to consider that ADRC differentiated to a nerve and blood vessel directly as the mechanism of the nerve regeneration by the ADRC transplantation, and was supposed that some kind of paracrine effects worked by ADRC porting.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2017 2016

All Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Development of New Peripheral Nerve Regeneration TherapyUsing Human Adipose Tissue-Derived Regenerative Cells for Peripheral Nerve Regeneration.2017

    • Author(s)
      Yumio Fujioka, Naosuke Kamei, Kazunori Yokota, Nobuo Adachi, Mitsuo Ochi.
    • Organizer
      Orthopaedic Research Society 2017 annual meeting
    • Place of Presentation
      San Diego, CA, U.S.A.(San Diego Convention Center)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヒト脂肪組織由来再生細胞(Adipose Tissue Derived Regenerative Cell: ADRC)を用いた末梢神経再生促進療法2016

    • Author(s)
      藤岡弓朗、亀井直輔、横田和典、安達伸生、越智光夫
    • Organizer
      第31回日本整形外科学会基礎学術集会
    • Place of Presentation
      福岡国際会議場(福岡市博多区)
    • Year and Date
      2016-10-13
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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