| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
Heat shock protein 70 (Hsp70) is expressed at high levels in cancer cells and attenuates the therapeutic efficacy of anticancer agents, resulting in a poorer prognosis. The objective of this study was to investigate if inhibition of Hsp70 expression in cultured osteosarcoma cells might enhance sensitivity of the cells to cisplatin.When cisplatin was administered under the inhibitory condition of Hsp70, the antitumor effect of cisplatin was significantly enhanced.This result suggested that suppression of Hsp70 could be a new adjuvant therapy for chemotherapy for osteosarcoma.
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