| Project/Area Number |
26462274
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
MURATA Hiroaki 京都府立医科大学, 医学(系)研究科(研究院), 客員講師 (90360031)
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| Co-Investigator(Kenkyū-buntansha) |
小藤 和孝 明治国際医療大学, 医学教育研究センター, 准教授 (50649340)
芦原 英司 京都薬科大学, 薬学部, 教授 (70275197)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ビスホスホネート / 転移性骨腫瘍 / 骨肉腫 / 軟部肉腫 / 骨セメント / ハイドロキシアパタイト / 徐放 / parathyroid Hormone / 超音波 |
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| Outline of Final Research Achievements |
Bisphosphonates (BPs) show anti-tumor effects against many malignant tumors. However, for clinical applications, a novel approach is needed to maintain a high concentration of BP for prolonged tumor exposure. Hydroxyapatite (HA) and bone cement are used in orthopedic surgery as a sustained-release system for drugs. Therefore, the present study assessed the effects of BPs-loaded HA and bone cement in metastatic sites of malignant tumor cells in vitro and in vivo. The antitumor effects of BPs -loaded HA were less potent compared with those of BPs -loaded bone cement in several malignant tumor cell lines. Moreover, BPs -loaded bone cement also exerted antitumor effects against pulmonary metastases and primary lesions, without exhibiting systemic toxicity in vivo.
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