• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Therapeutic effect of CD271 + BMSc and hyaluronic acid injection for the animal model of spontaneous osteoarthritis

Research Project

Project/Area Number 26462288
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionUniversity of Fukui

Principal Investigator

Miyazaki Tsuyoshi  福井大学, 学術研究院医学系部門(附属病院部), 講師 (80324169)

Co-Investigator(Kenkyū-buntansha) 内田 研造  福井大学, 医学部, 教授 (60273009)
坂本 拓己  福井大学, 医学部附属病院, 医員 (40634837)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords変形性膝関節症 / 軟骨再生 / MIAモデル / ヒアルロン酸 / CD271 / BMSc / 脂肪由来幹細胞 / guineapig / OA自然発症動物モデル
Outline of Final Research Achievements

At 5 weeks post transplantation, partial cartilage repair was noted in the HA-MSC group but not in the other groups. Examination of CFDA-SE-labeled cells demonstrated migration, differentiation, and proliferation of MSC in the HA-MSC group. There was strong immunostaining for type II collagen around both residual chondrocytes and transplanted MSCs in the OA cartilage.
This scaffold-free and technically undemanding technique appears to result in the regeneration of articular cartilage in the spontaneous OA animal model. Although further examination of the long-term effects of transplantation is necessary, the findings suggest that intra-articular injection of HA-MSC mixture is potentially beneficial for OA.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2014

All Presentation (3 results)

  • [Presentation] 変形性関節症動物モデルにおけるヒアルロン酸の治療効果2016

    • Author(s)
      宮崎剛, 坂本拓己, 本定和也, 竹浦直人, 佐藤充彦, 内田研造
    • Organizer
      第89回日本整形外科学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] MIA関節内注入OAモデルに対する間葉系幹細胞移植を用いた変形性関節症予防効果と疼痛関連因子の免疫組織学的評価2016

    • Author(s)
      坂本拓己, 宮崎剛, 本定和也, 高橋藍, 北出誠, 中嶋秀明, 内田研造
    • Organizer
      第89回日本整形外科学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2016-05-12
    • Related Report
      2015 Research-status Report
  • [Presentation] 変形性関節症自然発症動物モデルに対するヒアルロン酸関節内注入後の痛みの評価―後根神経節における免疫組織学的検討―2014

    • Author(s)
      宮崎 剛、内田研造、坂本拓己、本定和也、犬飼智雄、馬場久敏
    • Organizer
      第7回日本運動器疼痛学会
    • Place of Presentation
      宇部(ANAクラウンプラザホテル宇部)
    • Year and Date
      2014-10-25 – 2014-10-26
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi