| Project/Area Number |
26462294
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
松本 知之 神戸大学, 医学部附属病院, 講師 (50546588)
黒坂 昌弘 神戸大学, 医学研究科, 教授 (70170115)
黒田 良祐 神戸大学, 医学研究科, 教授 (80379362)
高山 孝治 神戸大学, 医学部附属病院, 助教 (80546490)
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| Research Collaborator |
NISHIDA Kyohei
INOKUCHI Takao
SHURONG Zhang
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 変形性関節症 / SIRT1 |
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| Outline of Final Research Achievements |
To date, no drugs to delay progression of osteoarthritis have been developed. The current study examined whether SIR1 can prevent progression of osteoarthritis. Osteoarthritis model was surgically created in mice and SRT1720 was administered systemically for 4-16 weeks. Osteoarthritis progression was examined by histology. Osteoarthritis progression was delayed at 8 and 12 weeks after surgery. Decreased cartilage degrading enzymes, chondrocyte death and synovitis were associated with the delayed osteoarthritis progression in the mice treated with SRT1720. Our observations suggested a potential treatment of osteoarthritis by SIRT1 activators.
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