| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Outline of Final Research Achievements |
We demonstrated that antagonists to TRPV1, ASIC and P2X2 improved the threshold value of pain-like behavior in OVX mice. These results suggest that the activation of these nociceptors by pathological conditions as acidic environment resulting from osteoclast activation cause skeletal pain in osteoporosis. We also demonstrated that an array of nociceptors, TRPV1, ASIC and P2X2/3, were simultaneously expressed in bone tissue under a high bone turnover state in OVX mice. In addition, the pain-like behaviors in tail-suspended mice were significantly increased in comparison with those in control mice. These mice showed regional osteoporotic changes in the hind limbs accompanied by an increase in bone resorption due to osteoclast activation. The pain-like behaviors accompanying the regional osteoporotic changes were significantly improved by the resumption of weight bearing, or treatment with bisphosphonate or acid-sensing nociceptor antagonists.
|
