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Establishment of the double-contrast agent -an effort to detect the rabbit knee cartilage degeneration in the early stage-

Research Project

Project/Area Number 26462311
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Orthopaedic surgery
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Ikoma Kazuya  京都府立医科大学, 医学(系)研究科(研究院), 講師 (50516044)

Co-Investigator(Kenkyū-buntansha) 徳永 大作  京都府立医科大学, 医学(系)研究科(研究院), 准教授 (90343409)
Research Collaborator KIDO Masamitsu  
ONISHI Okkihiro  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords整形外科学 / MRI / 関節軟骨 / 造影剤
Outline of Final Research Achievements

MRI is used recently to assess the degeneration of articular cartilage. However articular cartilage is a thin layer and has same signal intensity as the joint fluid, so it is difficult to distinguish between the articular cartilage and the adjacent joint fluid on MR images. To depict the articular cartilage, we obtained MR images after injecting a contrast agent with manganese ion. The agent depressed the signal intensity of the joint fluid, which made a contrast between the articular cartilage and the joint fluid. This new method enabled us to visualize the articular cartilage more vividly and in the earlier stage than the conventional method.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (16 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (12 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] 卒後研修講座 足・足関節部におけるMRI2015

    • Author(s)
      生駒和也
    • Journal Title

      整形外科

      Volume: 66 Pages: 159-164

    • NAID

      40020332120

    • Related Report
      2014 Research-status Report
  • [Journal Article] 【足部疾患の画像診断-撮りかた・見かたのコツ-】 MRI 足関節・足部のMRIの基礎2014

    • Author(s)
      生駒和也
    • Journal Title

      Orthopaedics

      Volume: 27 Pages: 39-46

    • Related Report
      2014 Research-status Report
  • [Journal Article] Selective visualization of rabbit knee cartilage using MR imaging with a double-contrast agent.2014

    • Author(s)
      Kido M, Ikoma K, Hara Y, Matsuda K I, Kawata M, Umeda M, and Kubo T
    • Journal Title

      J Magn Reson Imaging

      Volume: 39 Issue: 5 Pages: 1186-1190

    • DOI

      10.1002/jmri.24282

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 19. Evaluation of femoral perfusion in a rabbit model of steroid-induced osteonecrosis by dynamic contrast-enhanced MRI with a high magnetic field MRI system2014

    • Author(s)
      Hayashi S, Fujioka M, Ikoma K, Saito M, Ueshima K, Ishida M, Kuribayashi M, Ikegami A, Mazda O, Kubo T
    • Journal Title

      J Magn Reson Imaging

      Volume: 39 Issue: 4 Pages: 935-940

    • DOI

      10.1002/jmri.24632

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] MRI Using a Double-contrast Agent for Detection of Rabbit Knee Cartilage Degeneration2017

    • Author(s)
      Onishi O, Ikoma K, Kido M, Hayashi S, Kabuto Y, Matsuda K, Tanaka M, Kubo T.
    • Organizer
      Orthopaedic Research Society 2017 Annual Meeting
    • Place of Presentation
      サンディエゴ (アメリカ)
    • Year and Date
      2017-03-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] MRI with a double-contrast agent may enable us to detect early degenerative change of articular cartilage2016

    • Author(s)
      Onishi O, Ikoma K, Kido M, Kabuto Y, Tanaka M, Matsuda K, Kubo T.
    • Organizer
      24th Annual Meeting of the European Orthopaedic Research Society
    • Place of Presentation
      ボローニャ (イタリア)
    • Year and Date
      2016-09-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] Double-contrast Agent for Detection of Rabbit Knee Cartilage Degeneration2016

    • Author(s)
      Onishi O, Ikoma K, Kido M, Hayashi S, Minami M, Matsuda K, Tanaka M, Kubo T.
    • Organizer
      The 27th International Conference on Magnetic Resonance in Biological Systems
    • Place of Presentation
      京都
    • Year and Date
      2016-08-21
    • Related Report
      2016 Annual Research Report
  • [Presentation] Detection of Rabbit Knee Cartilage Degeneration Using a New Double-contrast Agent2016

    • Author(s)
      Okihiro Onishi, Kazuya Ikoma, Masamitsu Kido, Shigeki Hayashi, Yukichi Kabuto, Ken-ichi Matsuda, Toshikazu Kubo
    • Organizer
      ORS 2016 annual meeting
    • Place of Presentation
      Disney's Coronado Springs Resort, Florida, USA
    • Year and Date
      2016-03-05
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 足関節脱臼骨折に対するMR画像解析2015

    • Author(s)
      城戸 優充, 生駒 和也, 原 佑輔, 今井 寛, 牧 昌弘, 大橋 鈴世, 久保 俊一
    • Organizer
      第40回日本足の外科学会学術集会
    • Place of Presentation
      千葉県浦安市ヒルトン東京ベイ
    • Year and Date
      2015-10-29
    • Related Report
      2015 Research-status Report
  • [Presentation] MRIによる関節軟骨直接二重造影法を用いた変性関節軟骨の評価2015

    • Author(s)
      大西 興洋, 生駒 和也, 城戸 優充, 林 成樹, 加太 佑吉, 河田 光博, 久保 俊一
    • Organizer
      第回日本整形外科学会基礎学術集会
    • Place of Presentation
      富山県富山市富山国際会議場
    • Year and Date
      2015-10-22
    • Related Report
      2015 Research-status Report
  • [Presentation] T2マッピング法を用いた鏡視下半月板部分切除術前後の軟骨評価2015

    • Author(s)
      加藤 勘明, 新井 祐志, 生駒 和也, 中川 周士, 井上 裕章, 菅 寛之, 久保 俊一
    • Organizer
      第7回日本関節鏡・膝・スポーツ整形外科学会
    • Place of Presentation
      北海道札幌市札幌コンベンションセンター
    • Year and Date
      2015-06-18
    • Related Report
      2015 Research-status Report
  • [Presentation] MRI T2マッピング法を用いた鏡視下半月板部分切除後早期の軟骨評価2015

    • Author(s)
      新井 祐志, 加藤 勘明, 生駒 和也, 本城 邦晃, 中川 周士, 井上 裕章, 井上 敦夫, 原 邦夫, 久保 俊一
    • Organizer
      第88回日本整形外科学会学術総会
    • Place of Presentation
      兵庫県神戸市神戸国際会議場
    • Year and Date
      2015-05-21
    • Related Report
      2015 Research-status Report
  • [Presentation] A Trial To Detect Early Degenerative Changes Of Rabbit Knee Cartilage In Vivo Using MR Imaging With A Double-contrast Agent2015

    • Author(s)
      Shigeki Hayashi, Kazuya Ikoma, et al
    • Organizer
      2015 Annual Meeting of the Orthopaedic Research Society
    • Place of Presentation
      米国、ラスベガス
    • Year and Date
      2015-03-28 – 2015-03-31
    • Related Report
      2014 Research-status Report
  • [Presentation] 形性足関節症における距骨関節軟骨の T 2 マッピングによる評価法2014

    • Author(s)
      城戸優充、生駒和也、他
    • Organizer
      第39回日本足の外科学会・学術集会
    • Place of Presentation
      日本、宮崎
    • Year and Date
      2014-11-14
    • Related Report
      2014 Research-status Report
  • [Presentation] 林 成樹、生駒和也、他2014

    • Author(s)
      MRIによる直接二重造影法を用いたin vivoでの家兎膝関節軟骨評価
    • Organizer
      第29回日本整形外科学会基礎学術集会
    • Place of Presentation
      日本、鹿児島
    • Year and Date
      2014-10-09
    • Related Report
      2014 Research-status Report
  • [Presentation] T2 mapping of the articular cartilage of the talus in patients with ankle osteoarthritis2014

    • Author(s)
      Masamitsu Kido, Kazuya Ikoma, et al.
    • Organizer
      5th International Federatioin of Foot and Ankle Society
    • Place of Presentation
      米国、シカゴ
    • Year and Date
      2014-09-19 – 2014-09-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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