Role of chondrocyte DNA repair enzymes in the degeneration of articular cartilage in osteoarthritis.
| Project/Area Number |
26462323
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | St. Marianna University School of Medicine |
|---|
Principal Investigator |
YUDO KAZUO 聖マリアンナ医科大学, 医学研究科, 教授 (60272928)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
油井 直子 聖マリアンナ医科大学, 医学部, 講師 (20266696)
唐澤 里江 聖マリアンナ医科大学, 医学研究科, 講師 (50434410)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 変形性関節症 / 軟骨細胞 / 核酸修復酵素 / 核酸損傷修復酵素 / 軟骨変性 / メカニカルストレス / 酸化ストレス / 細胞エネルギー代謝 / ATPエネルギー / DNA修復酵素 / 活性酸素種 |
|---|
| Outline of Final Research Achievements |
Aging is one of the major pathologic factors associated with osteoarthritis (OA). It has been indicated that the NAD-dependent deacetylase sirtuin-1 (Sirt-1) has an important role in human aging.It has been suggested that Sirt-1 promotes osteogenic and chondrogenic differentiation of mesenchymal stem cells.
We postulated that Sirt-1 regulates a hypertrophic chondrocyte lineage and osteophyte formation through the activation of osteogenic transcription factor Runx2 in osteoarthritic chondrocytes.Our findings suggest that the NAD-dependent deacetylase Sirt-1 may upregulate the osteophyte formation and the expression of cartilage degrading enzyme MMP-13 through the mechanism involving the acceleration of the osteogenic transcription factor Runx2 in OA cartilage tissues.
|
Report
(4 results)
Research Products
(17 results)
