| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
It has been reported that neonatal exposure to anesthetics causes neurodegeneration and subsequent behavioral abnormalities in animal models. On the other hand, the inhibitory effect of excessive gamma-aminobutyric acid (GABA) type A receptor signaling on the granule cell migration in the neonatal rat dentate gyrus was reported in a febrile seizure model. Inhaled anesthetics is known to have GABAergic effect. In the present study, using immunohistochemical methods, it is revealed that neonatal exposure to inhaled anesthetics agents disturbs the migration of granule cell in the rat dentate gyrus and GABA(A) receptor is implicated in the inhibitory effect.
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