neuroprotection by the maintenance of blood brain barrier

• Project/Area Number: 26462334
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Gifu University
• Principal Investigator: Tanabe Kumiko 岐阜大学, 大学院医学系研究科, 准教授 (30402209)
• Co-Investigator(Kenkyū-buntansha): 小澤 修 岐阜大学, 大学院医学系研究科, 教授 (90225417)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 中枢神経保護 / サイトカイン / 細胞内情報伝達 / IL-1β / IL-6 / cAMP / STAT3 / interleukin-1β / interleukin-6 / グリア細胞

Outline of Final Research Achievements

It has been reported that interleukin (IL)-1β induces IL-6 synthesis in rat glioma cell line, C6 cells and that cAMP enhances IL-1β-induced IL-6 synthesis. We investigated the details behind enhancement of IL-1β-induced IL-6synthesis by cAMP.
In conclusion, adenylyl cyclase/cAMP/PKA pathway upregulates IL-1β-induced IL-6 synthesis through enhancement of the JAK2/STAT3 pathway. In addition, dexmedetomidine, intravenous anesthetic agent, inhibits IL-1β-induced IL-6 synthesis independently of the adenylyl cyclase/cAMP pathway through its receptor (α2 adrenoceptor).

Research Products

• [Journal Article] cAMP/PKA enhances interleukin-1β-induced interleukin-6 synthesis through STAT3 in glial cells (2016)
  • Author(s): Tanabe K, Kozawa O, Iida H
  • Journal Title: Cell Signal Volume: 28 Issue: 1 Pages: 19-24
  • DOI: 10.1016/j.cellsig.2015.10.009
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase. (2015)
  • Author(s): Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H.
  • Journal Title: Prostaglandins Leukot Essent Fatty Acids. Volume: 94 Pages: 73-81
  • DOI: 10.1016/j.plefa.2014.11.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Safe use of rocuronium for a post-polio syndrome patient (2015)
  • Author(s): Tanabe K, Takahashi H, Iida H
  • Journal Title: J Anesth Volume: 29 Issue: 2 Pages: 316-316
  • DOI: 10.1007/s00540-014-1906-7
  • Peer Reviewed
• [Journal Article] Effects of topical and intravenous JM-1232(-) infusion on cerebrovascular reactivity in rats (2015)
  • Author(s): Iwata K, Iida H, Iida M, Fukuoka N, Kito K, Tanabe K
  • Journal Title: J Anesth Volume: 29 Issue: 5 Pages: 798-802
  • DOI: 10.1007/s00540-015-2017-9
  • Peer Reviewed
• [Journal Article] Effect of postoperative administration of pregabalin for post-thoracotomy pain: a randomized study (2015)
  • Author(s): Yoshimura N, Iida H, Takenaka M, Tanabe K, Yamaguchi S, Kitoh K, Shirahashi K, Iwata H
  • Journal Title: J Cardiothorac Vasc Anesth Volume: 29 Issue: 6 Pages: 1567-1572
  • DOI: 10.1053/j.jvca.2015.05.117
  • Peer Reviewed
• [Journal Article] Dexmedetomidine suppresses interleukin-1β-induced interleukin-6 synthesis in rat glial cells. (2014)
  • Author(s): Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H.
  • Journal Title: Int J Mol Med. Volume: 34(4) Issue: 4 Pages: 1032-1038
  • DOI: 10.3892/ijmm.2014.1863
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons. (2014)
  • Author(s): Zhang L, Tanabe K, Yanagidate F, Kawasaki Y, Chen G, Dohi S, Iida H
  • Journal Title: European Journal of Pharmacology Volume: In Press Pages: 132-136
  • DOI: 10.1016/j.ejphar.2014.03.048
  • Peer Reviewed
• [Journal Article] Differential effects of intravenous anesthetics on PDGF-BB-induced vascular smooth muscle cell migration. (2014)
  • Author(s): Iida M, Tanabe K, Kozawa O, Iida H.
  • Journal Title: Cell Physiol Biochem. Volume: 33(6) Issue: 6 Pages: 1827-1837
  • DOI: 10.1159/000362961
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 脳の中のheat shock protein (2015)
  • Author(s): 田辺久美子、小澤 修、飯田宏樹
  • Organizer: 日本麻酔科学会第62回学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-05-28
• [Book] 虚血性中枢神経障害の基礎と臨床 (2016)
  • Author(s): 田辺久美子, 飯田宏樹
  • Publisher: 真興交易