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neuroprotection by the maintenance of blood brain barrier

Research Project

Project/Area Number 26462334
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionGifu University

Principal Investigator

Tanabe Kumiko  岐阜大学, 大学院医学系研究科, 准教授 (30402209)

Co-Investigator(Kenkyū-buntansha) 小澤 修  岐阜大学, 大学院医学系研究科, 教授 (90225417)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords中枢神経保護 / サイトカイン / 細胞内情報伝達 / IL-1β / IL-6 / cAMP / STAT3 / interleukin-1β / interleukin-6 / グリア細胞
Outline of Final Research Achievements

It has been reported that interleukin (IL)-1β induces IL-6 synthesis in rat glioma cell line, C6 cells and that cAMP enhances IL-1β-induced IL-6 synthesis. We investigated the details behind enhancement of IL-1β-induced IL-6synthesis by cAMP.
In conclusion, adenylyl cyclase/cAMP/PKA pathway upregulates IL-1β-induced IL-6 synthesis through enhancement of the JAK2/STAT3 pathway. In addition, dexmedetomidine, intravenous anesthetic agent, inhibits IL-1β-induced IL-6 synthesis independently of the adenylyl cyclase/cAMP pathway through its receptor (α2 adrenoceptor).

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 8 results,  Acknowledgement Compliant: 4 results,  Open Access: 1 results) Presentation (1 results) Book (1 results)

  • [Journal Article] cAMP/PKA enhances interleukin-1β-induced interleukin-6 synthesis through STAT3 in glial cells2016

    • Author(s)
      Tanabe K, Kozawa O, Iida H
    • Journal Title

      Cell Signal

      Volume: 28 Issue: 1 Pages: 19-24

    • DOI

      10.1016/j.cellsig.2015.10.009

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Rho-kinase regulates human platelet activation induced by thromboxane A2 independently of p38 MAP kinase.2015

    • Author(s)
      Iida Y, Doi T, Tokuda H, Matsushima-Nishiwaki R, Tsujimoto M, Kuroyanagi G, Yamamoto N, Enomoto Y, Tanabe K, Otsuka T, Iwama T, Ogura S, Kozawa O, Iida H.
    • Journal Title

      Prostaglandins Leukot Essent Fatty Acids.

      Volume: 94 Pages: 73-81

    • DOI

      10.1016/j.plefa.2014.11.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Safe use of rocuronium for a post-polio syndrome patient2015

    • Author(s)
      Tanabe K, Takahashi H, Iida H
    • Journal Title

      J Anesth

      Volume: 29 Issue: 2 Pages: 316-316

    • DOI

      10.1007/s00540-014-1906-7

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of topical and intravenous JM-1232(-) infusion on cerebrovascular reactivity in rats2015

    • Author(s)
      Iwata K, Iida H, Iida M, Fukuoka N, Kito K, Tanabe K
    • Journal Title

      J Anesth

      Volume: 29 Issue: 5 Pages: 798-802

    • DOI

      10.1007/s00540-015-2017-9

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of postoperative administration of pregabalin for post-thoracotomy pain: a randomized study2015

    • Author(s)
      Yoshimura N, Iida H, Takenaka M, Tanabe K, Yamaguchi S, Kitoh K, Shirahashi K, Iwata H
    • Journal Title

      J Cardiothorac Vasc Anesth

      Volume: 29 Issue: 6 Pages: 1567-1572

    • DOI

      10.1053/j.jvca.2015.05.117

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dexmedetomidine suppresses interleukin-1β-induced interleukin-6 synthesis in rat glial cells.2014

    • Author(s)
      Tanabe K, Matsushima-Nishiwaki R, Kozawa O, Iida H.
    • Journal Title

      Int J Mol Med.

      Volume: 34(4) Issue: 4 Pages: 1032-1038

    • DOI

      10.3892/ijmm.2014.1863

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons.2014

    • Author(s)
      Zhang L, Tanabe K, Yanagidate F, Kawasaki Y, Chen G, Dohi S, Iida H
    • Journal Title

      European Journal of Pharmacology

      Volume: In Press Pages: 132-136

    • DOI

      10.1016/j.ejphar.2014.03.048

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Differential effects of intravenous anesthetics on PDGF-BB-induced vascular smooth muscle cell migration.2014

    • Author(s)
      Iida M, Tanabe K, Kozawa O, Iida H.
    • Journal Title

      Cell Physiol Biochem.

      Volume: 33(6) Issue: 6 Pages: 1827-1837

    • DOI

      10.1159/000362961

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 脳の中のheat shock protein2015

    • Author(s)
      田辺久美子、小澤 修、飯田宏樹
    • Organizer
      日本麻酔科学会第62回学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2015-05-28
    • Related Report
      2015 Research-status Report
  • [Book] 虚血性中枢神経障害の基礎と臨床2016

    • Author(s)
      田辺久美子, 飯田宏樹
    • Publisher
      真興交易
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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