| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
To clarify the influence of nociception on spinal synaptic transmission, we assessed the NK1 recepter internalization (NK1Ri) and optical synaptic imaging using brain vision. The nocicetive behavior induced by formalin injection was significantly enhanced in mutant mice lacking DAO. The number of NK1Ri positive neurons was increased by formalin injection in ipsilateral dorsal horn. Furthermore, electrical stimulation of dorsal root ganglion attenuated the fluorescent change of voltage-sensitive dye in dorsal horn.
These results suggest that DAO is involved to the nociceptive synaptic transmission in spinal dorsal horn.
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