Search of the effective cerebroprotection method in cerebral ischaemia which utilized brain environment derived from a transporter
| Project/Area Number |
26462347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
佐藤 永一 東京医科大学, 医学部, 准教授 (60408101)
武田 明子 東京医科大学, 医学部, 助教 (70421021)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 脳虚血 / P-glycoprotein / マウス / 脳内トランスポーター |
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| Outline of Final Research Achievements |
We discovered that P-glycoprotein (P-gp) which is one of the intracerebral transporters not only regulates the intracerebral penetrance of the drug, but also influences damage of cerebral ischemia. Furthermore, we confirmed that presence of P-gp has an influence for cytokine and an apoptotic material related for cerebral ischemia. We also showed the tendency that the combination with P-gp inhibitor and cerebroprotection agent strengthens cerebroprotection effects. In this project, we investigated utilization of the P-gp inhibitor to show the effects of the cerebroprotection agent in consideration of effects of P-gp in cerebral ischemia.
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Report
(4 results)
Research Products
(1 results)
