Search of the effective cerebroprotection method in cerebral ischaemia which utilized brain environment derived from a transporter

Research Project

Project/Area Number	26462347
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Anesthesiology
Research Institution	Tokyo Medical University
Principal Investigator	MUROZONO MICHIHIRO 東京医科大学, 医学部, 准教授 (70276947)
Co-Investigator(Kenkyū-buntansha)	佐藤永一東京医科大学, 医学部, 准教授 (60408101) 武田明子東京医科大学, 医学部, 助教 (70421021)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000) Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	脳虚血 / P-glycoprotein / マウス / 脳内トランスポーター
Outline of Final Research Achievements	We discovered that P-glycoprotein (P-gp) which is one of the intracerebral transporters not only regulates the intracerebral penetrance of the drug, but also influences damage of cerebral ischemia. Furthermore, we confirmed that presence of P-gp has an influence for cytokine and an apoptotic material related for cerebral ischemia. We also showed the tendency that the combination with P-gp inhibitor and cerebroprotection agent strengthens cerebroprotection effects. In this project, we investigated utilization of the P-gp inhibitor to show the effects of the cerebroprotection agent in consideration of effects of P-gp in cerebral ischemia.