| Project/Area Number |
26462348
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
諸田 沙織 東京医科大学, 医学部, 助教 (30719711)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | シノビオリン / 敗血症性脳症 / メタボローム / ユビキチンリガーゼ / KAT / キヌレニン / KAT4 / 敗血症 / シノビオリンＫＯマウス / ＣＬＰモデル / 脳内シノビオリン(Syvn) / SyvncKOマウス / 神経細胞死 / 敗血症性脳症(SE) / ERAD |
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| Outline of Final Research Achievements |
In this study, we focus on cerebral synoviolin (Syvn) as a ubiquitin ligase (E3) involved in endoplasmic reticulum-related degradation mechanism, the mechanism of septic encephalopathy (SE) was investigated. As a result,1 Metabolome analysis of intracerebral metabolic pathway via Syvn showed a marked decrease in kynurenic acid and a significant increase in kynurenine at 18 hours after SE onset. It became clear that kynurenine plays an important role in inducing the impaiment of the brain. 2 KAT activity by SE was increased, especially, activity of KAT4 significantly increased 18 hours after CLP model creation. Conclusion: Suppression of Syvn and reduction of kinurenine suppresses neuropathy and it may lead to improvement of septic encephalopathy.
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