Early detection of left ventricular assist device associated acute kidney injury using new markers

• Project/Area Number: 26462358
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Anesthesiology
• Research Institution: Osaka University
• Principal Investigator: Iguchi Naoya 大阪大学, 医学系研究科, 招へい教員 (00372623)
• Co-Investigator(Kenkyū-buntansha): 藤野 裕士 大阪大学, 医学系研究科, 教授 (50252672) ; 内山 昭則 大阪大学, 医学系研究科, 准教授 (00324856)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 腎臓超音波検査 / 定常流型補助人工心臓

Outline of Final Research Achievements

The patients who underwent continuous flow type left ventricular assist devices were examined. We performed renal ultrasonography and identified flow velocity at inter lober artery and color pixel counts in whole kidney area. Color pixel counts were different between patients who recover from acute kidney injury (AKI) and did not recover from AKI (17.6(14.0-20.6)、2.6(1.2-3.3), respectively). Our finding suggest that color pixel counts in whole kidney area may be useful for monitoring the status and treatment of left ventricular assist devices associated AKI.

Research Products

• [Int'l Joint Research] フローリー研究所、メルボルン大学(オーストラリア)
• [Journal Article] Effects of low-dose atrial natriuretic peptide infusion on cardiac surgery associated acute kidney injury: A multicenter randomized controlled trial (2017)
  • Author(s): Chieko Mitaka, Tetsu Ohnuma, Takanori Murayama, Fumio Kunimoto, Michio Nagashima, Tetsuhiro Takei, Naoya Iguchi, Makoto Tomita, for the JAPAN Investigators
  • Journal Title: Journal of Critical Care Volume: 38 Pages: 253-258
  • DOI: 10.1016/j.jcrc.2016.12.004
  • Peer Reviewed / Open Access
• [Journal Article] Direct cerebral perfusion and cooling in experimental cardiac arrest (2016)
  • Author(s): Rinaldo Bellomo, Bruno Marino, Peter Angelopoulos, Scott Carson, Glenn Eastwood, Junko Kosaka, Naoya Iguchi, Andrew Hilton, Clive May
  • Journal Title: Critical Care and Resuscitation Volume: 18 Pages: 255-260
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neutrophil gelatinase-associated lipocalin and liver-type fatty acid-binding protein as biomarkers for acute kidney injury after organ transplantation (2015)
  • Author(s): Naoya Iguchi, Akinori Uchiyama, Kazuyoshi Ueta, Yoshiki Sawa, Yuji Fujino
  • Journal Title: J Anesth Volume: 29 Issue: 2 Pages: 249-255
  • DOI: 10.1007/s00540-014-1909-4
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm: a prospective observational study (2014)
  • Author(s): Kazuyoshi Ueta, Michiko Watanabe, Naoya Iguchi, Akinori Uchiyama, Yukitoshi Shirakawa, Toru Kuratani, Yoshiki Sawa, Yuji Fujino
  • Journal Title: Journal of Intensive Care Volume: 2:45 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s40560-014-0045-4
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Superb Micro Vascular Imaging法で腎血流評価を行った定常流型左室補助人工心臓装着術後急性腎傷害の検討 (2017)
  • Author(s): 酒井佳奈紀、井口直也、内山昭則、藤野裕士
  • Organizer: 第60回日本腎臓学会学術総会
  • Place of Presentation: 仙台市
  • Year and Date: 2017-05-27
• [Presentation] EFFECTS OF GENERAL ANAESTHESIA AND INSPIRED OXYGEN FRACTION ON SYSTEMIC AND RENAL HAEMODYNAMICS AND INTRA-RENAL OXYGENATION IN SHEEP (2016)
  • Author(s): Naoya Iguchi, Yugeesh Lankadeva, Junko Kosaka, Roger Evans, Clive May
  • Organizer: Joint Annual Scientific Meeting of AAS, HBPRCA and AVBS 2016
  • Place of Presentation: Hobart, Australia
  • Year and Date: 2016-12-09
  • Int'l Joint Research
• [Presentation] RELATIONSHIP BETWEEN SEVERE HYPERCALCEMIA AND MORTALITY IN POST-LIVER TRANSPLANT PATIENTS: A RETROSPECTIVE CASE-CONTROL STUDY (2016)
  • Author(s): Kanaki Sakai, Naoya Iguchi, Hirotsugu Iwatani, Akinori Uchiyama, Yuji Fujino
  • Organizer: 41st ANZICS/ACCCN INTENSIVE CARE ASM
  • Place of Presentation: Perth, Australia
  • Year and Date: 2016-10-20
  • Int'l Joint Research
• [Presentation] 超音波検査Superb Micro Vascular Imaging（SMI法）で腎血流評価を行った定常流型左室補助人工心臓（LVAD）装着術術後急性腎傷害の１症例 (2016)
  • Author(s): 酒井佳奈紀、井口直也、平松大典、松本充弘、田中愛子、廣瀬将樹、内山昭則、藤野裕士
  • Organizer: 第61回日本集中治療医学会近畿地方会
  • Place of Presentation: 大阪市
  • Year and Date: 2016-07-09
• [Presentation] 腎臓超音波検査を用いた定常流型補助人工心臓装着患者での腎機能評価の試み (2016)
  • Author(s): 井口 直也、酒井 佳奈紀、内山 昭則、藤野 裕士
  • Organizer: 第43回日本集中治療医学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2016-02-12
• [Presentation] Survey of the Argatroban Dose for Heparin-Induced Thrombocytopenia in Critically Ill Patients (2015)
  • Author(s): Naoya Iguchi, Akinori Uchiyama, Yuji Fujino
  • Organizer: 40TH ANZICS/ACCCN INTENSIVE CARE ANNUAL SCIENTIFIC MEETING
  • Place of Presentation: AUCKLAND, NEW ZEALAND
  • Year and Date: 2015-10-29
  • Int'l Joint Research
• [Presentation] No correlation between renal resistive index by ultrasonography and pulse pressure index in critically ill patients (2014)
  • Author(s): Naoya Iguchi, Akinori Uchiyama, Kanaki Sakai, Yuji Fujino
  • Organizer: ANZICS/ACCCN Intensive Care ASM
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2014-10-09 – 2014-10-11