| Project/Area Number |
26462360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
KAWAHITO Shinji 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (60284296)
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| Co-Investigator(Kenkyū-buntansha) |
北畑 洋 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (60161486)
松久 宗英 徳島大学, 先端酵素学研究所(糖尿病), 特任教授 (60362737)
高石 和美 徳島大学, 病院, 講師 (20325286)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 再生医療 / 血管新生 / 周術期管理法 / 血管プレコンディショニング / 周術期管理学 / プレコンディショニング |
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| Outline of Final Research Achievements |
We examined the influence of vascular preconditioning (hypoxic and remote preconditioning) on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of vascular preconditioning should be less. Basic experiments using cultured cells indicated endothelial cell migration was significantly stimulated with FBS (2% fetal bovine serum), however, vascular preconditioning did not show any significant enhancing or suppression effects on endothelial cell migration. It is hoped that a new indicator of the perioperative administration in established by the influence of vascular preconditioning which gives it to angiogenesis being elucidated.
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