Is angiogenesis in regenerative medicine influenced by vascular preconditioning?
Project/Area Number |
26462360
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Anesthesiology
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Research Institution | The University of Tokushima |
Principal Investigator |
KAWAHITO Shinji 徳島大学, 大学院医歯薬学研究部(医学系), 特任教授 (60284296)
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Co-Investigator(Kenkyū-buntansha) |
北畑 洋 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (60161486)
松久 宗英 徳島大学, 先端酵素学研究所(糖尿病), 特任教授 (60362737)
高石 和美 徳島大学, 病院, 講師 (20325286)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 再生医療 / 血管新生 / 周術期管理法 / 血管プレコンディショニング / 周術期管理学 / プレコンディショニング |
Outline of Final Research Achievements |
We examined the influence of vascular preconditioning (hypoxic and remote preconditioning) on angiogenesis in animal experiments, clinical studies, and basic experiments using cultured cells. Animal experiments and clinical studies revealed the effect on angiogenesis of vascular preconditioning should be less. Basic experiments using cultured cells indicated endothelial cell migration was significantly stimulated with FBS (2% fetal bovine serum), however, vascular preconditioning did not show any significant enhancing or suppression effects on endothelial cell migration. It is hoped that a new indicator of the perioperative administration in established by the influence of vascular preconditioning which gives it to angiogenesis being elucidated.
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Anesthetic management of a patient with unruptured sinus of Valsalve aneurysm with right ventricular outflow tract obstruction2016
Author(s)
Mita N, Kawahito S, Soga T, Katayama T, Wakamatsu N, Kawahara T, Kakuta N, Hamaguchi E, Tsytsumi YM, Tanaka K, Takaishi K, Kitahata H
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Journal Title
Circ Cont
Volume: 37
Pages: 195-198
Related Report
Peer Reviewed
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[Journal Article] Role of transesophageal echocardiography during biventricular pacemaker implantation in children2015
Author(s)
Nami Kakuta, Shinji Kawahito, Naoji Mita, Tomohiro Soga, Toshiko Katayama, Kohei Fukuta, Hiroaki Kawano, Fumihiko Tada, Yasui M Tsutsumi, Katsuya Tanaka, Kazumi Takaishi, Hiroshi Kitahata
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Journal Title
Clin Pediatr Anesth
Volume: 21
Pages: 182-185
Related Report
Peer Reviewed
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[Journal Article] Impact of newly developed, next-generation artificial endocrine pancreas2015
Author(s)
Kambe N, Kawahito S, Mita N, Takaishi K, Katayama T, Sakai Y, Soga T, Kawano H, Matsuhisa M, Shimada M, Kitagawa T, Kitahata H
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Journal Title
J Med Invest
Volume: 62
Pages: 41-44
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Usefulness of artificial endocrine pancreas during resection of insulinoma2014
Author(s)
Hirose K, Kawahito S, Mita N, Takaishi K, Kawahara T, Soga T, Katayama T, Imura S, Morina Y, Ikemoto T, Shimada M, Matsuhisa M, Kitahata H
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Journal Title
J Med Invest
Volume: 61
Pages: 421-425
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Role of intraoperative single-plane transesophageal echocardiography probe for infants with congenital heart disease2014
Author(s)
Kakuta N, Kawahito S, Soga T, Mita N, Fukuta K, Wakamatsu N, Sakai Y, Katayama T, Tada F, Takaishi K, Kitahata H
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Journal Title
Clin Pediatr Anesth
Volume: 20
Pages: 231-235
Related Report
Peer Reviewed
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[Presentation] Accuracy and reliability of continuous blood glucose monitoring during pediatric cardiopulmonary bypass2016
Author(s)
Satomi S, Kawahito S, Soga T, Mita N, Kakuta N, Hamaguchi E, Takaishi K, Kitahata H, Tsutsumi YM, Tanaka K
Organizer
2016 Annual Meeting of American Society of Anesthesiologists (ASA)
Place of Presentation
Chicago, USA
Year and Date
2016-10-22
Related Report
Int'l Joint Research
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[Presentation] TEE研究の方法(成人)2015
Author(s)
川人伸次、北畑 洋
Organizer
日本心臓血管麻酔学会第20回学術集会
Place of Presentation
アクロス福岡(福岡県福岡市)
Year and Date
2015-10-09
Related Report
Invited
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[Presentation] 体外循環の基礎2014
Author(s)
川人伸次
Organizer
第19回日本心臓血管麻酔学会
Place of Presentation
ホテル阪急エキスポパーク(大阪府、吹田市)
Year and Date
2014-09-20 – 2014-09-22
Related Report
Invited
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