| Project/Area Number |
26462368
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | International University of Health and Welfare (2016)
Yokohama City University (2014-2015) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
矢澤 卓也 獨協医科大学, 医学部, 教授 (50251054)
馬場 靖子 横浜市立大学, 附属市民総合医療センター, 講師 (80453041)
|
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| Co-Investigator(Renkei-kenkyūsha) |
SAITO Izumu 東京大学, 医科学研究所, 教授 (70158913)
|
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | ARDS / 再灌流傷害 / HIF / 低酸素 / アポトーシス / 再灌流障害 / 肺傷害 / 虚血再灌流障害 / 転写因子 / サイトカイン / 虚血 |
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| Outline of Final Research Achievements |
Ischemia occurs in accordance with hypoxia. It is well known that hypoxia-inducible factor (HIF)-1 expresses in hypoxic tissue and has an anti-inflammatory property. Acute respiratory distress syndrome (ARDS), a major cause of hypoxia, causes apoptosis through Fas/FasL pathway. Dimethyloxalylglycine (DMOG), a prolyl hydroxylase domain protein (PHD) inhibitor, suppresses Fas and thus diminishes apoptosis, which preserves the alveolar barrier function. Anti-apoptotic effects of DMOG and the suppression of Fas effects were not observed when HIF-1 pathway was inhibited by some ways such as siRNA. These findings suggest that anti-apoptotic effects of DMOG are dependent of HIF-1.
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