| Project/Area Number |
26462370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Yoshinobu Nakayama 京都府立医科大学, 医学(系)研究科(研究院), 助教 (90568198)
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| Co-Investigator(Kenkyū-buntansha) |
佐和 貞治 京都府立医科大学, 医学(系)研究科(研究院), 教授 (10206013)
溝部 俊樹 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50239266)
小川 覚 京都府立医科大学, 医学(系)研究科(研究院), 助教 (50636131)
中嶋 康文 関西医科大学, 医学部, 教授 (70326239)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血小板 / microRNA / micro RNA |
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| Outline of Final Research Achievements |
Currently, platelet function monitoring in the perioperative field has very limited clinical relevance. The present study was aimed to investigate the efficacy of using microRNAs in platelets as a method of platelet function monitoring. In the first step, we stimulated platelets with drugs and the application of shear stress, and compared the microRNA expressions in platelets between pre- and post-stimulation using next-generation sequencing technology. Comprehensive analyses by next-generation sequencing identified several microRNAs (including mir-155) exhibiting significant expression changes.
Focusing on the microRNAs showing significant changes in the first step, we will perform the next step using antiplatelet agents.
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