| Project/Area Number |
26462379
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | University of Toyama |
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Principal Investigator |
Yamazaki Mitsuaki 富山大学, 大学院医学薬学研究部(医学), 教授 (70158145)
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| Co-Investigator(Kenkyū-buntansha) |
成田 年 星薬科大学, 薬学部, 教授 (40318613)
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| Co-Investigator(Renkei-kenkyūsha) |
SAKAI Hiroyasu 星薬科大学, 薬学部, 助教 (00328923)
IKEGAMI Daigo 星薬科大学, 薬学部, 助教 (30619747)
TAKEMURA Yosinori 富山大学, 大学院医学薬学研究部(医学), 助教 (70624922)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 神経障害性疼痛 / 睡眠障害 / 縫線核 / 青斑核 / アミトリプチリン / オレキシン受容体拮抗薬 / 睡眠 / 脳波 / セロトニン / スボレキサント / ノルアドレナリン / マイクロダイアリシス / optogenetics |
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| Outline of Final Research Achievements |
Chronic neuropathic pain significantly interferes with sleep, and inadequate sleep may contribute to the negative consequences in the treatment of pain. In this study, we showed that the neuropathic pain accelerates the dorsal raphe nucleus (DRN)-serotonergic and the locus coeruleus (LC)-noradrenergic neurons. These activations in DRN and LC neurons may be, at least in part, responsible for sleep disorders under a neuropathic pain-like state. Amitriptyline, a tricyclic antidepressant, and suvorexant, a dual orexin receptor antagonist, could improve the secondary sleep disturbance induced by chronic neuropathic pain.
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