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Mechanisms of persistent postoperative pain after laparotomy and analgesic treatments

Research Project

Project/Area Number 26462380
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Anesthesiology
Research InstitutionShinshu University

Principal Investigator

TANAKA Satoshi  信州大学, 学術研究院医学系, 准教授 (60293510)

Co-Investigator(Kenkyū-buntansha) 杉山 由紀  信州大学, 学術研究院医学系, 助教 (10468100)
川真田 樹人  信州大学, 学術研究院医学系, 教授 (90315523)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords局所麻酔薬 / 術後痛 / 疼痛管理 / 局所麻酔
Outline of Final Research Achievements

The purpose of this study was to investigate the underlying mechanisms of severe pain after open abdominal surgery using our new animal model with laparotomy and appendectomy. Skin incision induced mechanical hyperalgesia in the surgical site but did not affect spontaneous locomotor activity. Laparotomy induced mechanical hyperalgesia not only in the surgical site but also in the site distant from the surgical site and reduced locomotor activity. The number of c-Fos-positive neurons in the thoracic dorsal horn in the laparotomy group was higher than that in the skin incision group, which were reduced by administration of a local anesthetic into the surgical site. Although there were no significant differences in the pain-related behaviors between the laparotomy and appendectomy groups, recovery from postoperative weight loss in the appendectomy group delayed. Spontaneous locomotor activity and area of mechanical hyperalgesia vary according to degree of the surgical stress.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Book (2 results)

  • [Journal Article] Spinal nociceptive transmission by mechanical stimulation of bone marrow.2016

    • Author(s)
      Ishida T, Tanaka S, Sekiguchi T, Sugiyama D, Kawamata M.
    • Journal Title

      Mol Pain.

      Volume: 12 Pages: 1-15

    • DOI

      10.1177/1744806916628773

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transversus abdominis plane block with 0.25 % levobupivacaine: a prospective, randomized, double‐blinded clinical study2015

    • Author(s)
      Ishida T, Sakamoto A, Tanaka H, Ide S, Ishida K, Tanaka S, Mori T, Kawamata M
    • Journal Title

      J Anesth

      Volume: 29 Issue: 4 Pages: 557-61

    • DOI

      10.1007/s00540-015-1993-0

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Calcitonin Gene-related Peptide Is Involved in Inflammatory Pain but Not in Postoperative Pain2014

    • Author(s)
      Ishida, K, Kawamata T, Tanaka S, Shindo T, Kawamata M
    • Journal Title

      Anesthesiology

      Volume: 121 Issue: 5 Pages: 1068-1079

    • DOI

      10.1097/aln.0000000000000364

    • NAID

      40020663802

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Successful intubation using McGRATH MAC in a patient with Treacher Collins syndrome.2014

    • Author(s)
      Tsujimoto T, Tanaka S, Yoshiyama Y, Sugiyama Y, Kawamata M.
    • Journal Title

      Middle East J Anaesthesiol

      Volume: 22 Pages: 523-5

    • Related Report
      2014 Research-status Report
  • [Presentation] Spontaneous exploratory activity, area of mechanical hyperalgesia, and expression of c-Fos protein in the spinal cord after abdominal surgery vary according to degree of the surgical stress2016

    • Author(s)
      Zhang H, Tanaka S, Sugiyama D, Kawamata M
    • Organizer
      International Association for the Study of Pain
    • Place of Presentation
      Pacifico Yokoyama Convention Center, Yokohama, Japan
    • Year and Date
      2016-09-26
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Book] 複合性局所疼痛症候群に対するインターベンション治療2014

    • Author(s)
      田中 聡、坂本明之、長櫓 巧、川真田樹人
    • Publisher
      日本末梢神経学会
    • Related Report
      2014 Research-status Report
  • [Book] CRPS-痛みの診療キーポイント2014

    • Author(s)
      田中 聡、川真田樹人
    • Total Pages
      107
    • Publisher
      文光堂
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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