| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The correlation between inflammation and acute postoperative pain was investigated using TRPA1-/- mice. In TRPA1-/- mice, mechanical threshold was not altered at the sites of incision. However, the number of neutrophils and M1 macrophages was significantly decreased on POD2. Similarly, M2 macrophages was decreased on POD7, whereas the production of TNF-α and COX-2 was increased. In late phase of postoperative period, pain intensity may not be consistent with the production of pro-inflammatory mediators.
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