The role of TRPA1 in postoperative pain and wound healing
| Project/Area Number |
26462383
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Kagoshima University |
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Principal Investigator |
Hasegawa Maiko 鹿児島大学, 医歯学域医学系, 准教授 (20516637)
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| Co-Investigator(Kenkyū-buntansha) |
桑木 共之 鹿児島大学, 医歯学域医学系, 教授 (80205260)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | TRPA1 / 術後痛 / 創傷治癒 / 急性炎症 / 手術侵襲 / 炎症 |
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| Outline of Final Research Achievements |
The correlation between inflammation and acute postoperative pain was investigated using TRPA1-/- mice. In TRPA1-/- mice, mechanical threshold was not altered at the sites of incision. However, the number of neutrophils and M1 macrophages was significantly decreased on POD2. Similarly, M2 macrophages was decreased on POD7, whereas the production of TNF-α and COX-2 was increased. In late phase of postoperative period, pain intensity may not be consistent with the production of pro-inflammatory mediators.
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Report
(4 results)
Research Products
(19 results)
