Application of tumor endothelial derived exosomal-miRNA for cancer diagnosis and therapy.
Project/Area Number |
26462388
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
|
Research Institution | Hokkaido University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
間石 奈湖 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
樋田 泰浩 北海道大学, 大学病院, 准教授 (30399919)
篠原 信雄 北海道大学, 医学研究科, 教授 (90250422)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 腎癌 / miRNA |
Outline of Final Research Achievements |
In this study, we have tried to identify tumor endothelial miRNAs which are exported by tumor exosome and induce cancer invasion and metastasis. Normal and tumor endothelial cells were isolated from human normal renal tissue and renal tumor tissue respectively. miRNAs were isolated from each endothelial cells and compared to each other by miRNA array. miRNA target genes were identified using public data base. Among miRNA which were picked up, we identified miRNA that induce cancer invasion and metastasis. These results suggested that tumor blood vessel affect cancer cell phenotype via miRNAs.
|
Report
(4 results)
Research Products
(24 results)
-
[Journal Article] Vasohibin-1 as a novel prognostic factor for head and neck squamous cell carcinoma2017
Author(s)
Torii C., Hida Y., Shindoh M., Akiyama K., Ohga N., Maishi N., Ohiro Y., Ono M., Totsuka Y., Kitagawa Y., Tei K., Sato Y., Hida K.
-
Journal Title
Anticancer Res
Volume: 37
Issue: 3
Pages: 1219-1225
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Aneuploidy of murine immortalized endothelial cell line, MS1.2017
Author(s)
Hida K., Maishi N., Dorcas Akuba-Muhyia Annan, Kondoh M., Hojo T., Umma Habiba, Ohga N., Ishikawa K, Sato M., Torii C., Yanagiya M., Morimoto M., Hida Y., Shindoh M.
-
Journal Title
J Oral Biosci
Volume: 59
Issue: 1
Pages: 50-54
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
[Journal Article] Tumor endothelial cells express high pentraxin 3 levels2016
Author(s)
Hida K., Maishi N., Kawamoto T., Akiyama K., Ohga N., Hida Y., Yamada K., Hojo T., Kikuchi H., Sato M., Torii C., Shinohara N., Shindoh M
-
Journal Title
Pathol Int
Volume: 66
Issue: 12
Pages: 687-694
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan.2016
Author(s)
N. Maishi, Y. Ohba, K. Akiyama, N. Ohga, J.I. Hamada, H. Nagao-Kitamoto, M. Alam, K. Yamamoto, T. Kawamoto, N. Inoue, A. Taketomi, M. Shindoh, Y. Hida and K. Hida.
-
Journal Title
Sci. Rep.
Volume: 6
Issue: 1
Pages: 28039-28039
DOI
NAID
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Prospective mapping of lymph node metastasis in Japanese patients undergoing radical cystectomy for bladder cancer: characteristics of micrometastasis2015
Author(s)
Matsumoto R, Takada N, Abe T, Minami K, Harabayashi T, Nagamori S, Hatanaka KC, Miyajima N, Tsuchiya K, Maruyama S, Murai S, Shinohara N
-
Journal Title
Japanese journal of clinical oncology
Volume: 45
Pages: 874-880
Related Report
Peer Reviewed
-
[Journal Article] Outcome of regional lymphadenectomy in accordance with primary tumor location on laparoscopic nephroureterectomy for urotheleal carcinoma of the upper urinary tract: A prospective study2015
Author(s)
Abe T, Takada N, Matsumoto R, Osawa T, Sazawa A, Maruyama S, Tsuchiya K, Harabayashi T, Minami K, Nagamori S, Hatanaka KC, Tanaka Y, Shinohara N, Nonomura K
-
Journal Title
Journal of endoruology
Volume: 29
Pages: 304-309
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Presentation] Tumor endothelial cells acquire drug resistance by exosomal-miR derived from high metastatic tumor2016
Author(s)
Hida K., Torii C., Maishi N., Morimoto M., Akiyama K., Kawamoto T., Minami T., Yoshioka Y., Mohammad Towfik Alam, Shindoh M., Hida Y., Ochiya T
Organizer
The 19th International Vascular Biology Meeting
Place of Presentation
Sheraton Boston Hotel(Boston,USA)
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-