| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Outline of Final Research Achievements |
In this study, we have tried to identify tumor endothelial miRNAs which are exported by tumor exosome and induce cancer invasion and metastasis. Normal and tumor endothelial cells were isolated from human normal renal tissue and renal tumor tissue respectively. miRNAs were isolated from each endothelial cells and compared to each other by miRNA array. miRNA target genes were identified using public data base. Among miRNA which were picked up, we identified miRNA that induce cancer invasion and metastasis. These results suggested that tumor blood vessel affect cancer cell phenotype via miRNAs.
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