| Project/Area Number |
26462390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
間石 奈湖 北海道大学, 遺伝子病制御研究所, 助教 (00632423)
土屋 邦彦 北海道大学, 大学病院, 助教 (50374442)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 腫瘍血管新生 / biglycan / 転移 / 腫瘍血管内皮 / biglycan, / LOX / biglycan, LOX |
|---|
| Outline of Final Research Achievements |
In this study, we addressed the involvement of tumor endothelial secreting molecule in cancer metastasis. Among these molecules, we focused on biglycan and analyzed the role of biglycan in cancer metastatic potential. We observed that biglycan-secreted from tumor endothelial cells activate NF-B and ERK in cancer cells and attract cancer cells towards tumor blood vessels, resulting in increase of lung metastasis. Furthermore, blood level of biglycan in cancer patients correlated with vascular invasion of cancer. These suggested that tumor endothelial secreting factor may be biomarker in cancer metastasis.
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