Inhibition of prostatic cancer through degradation of androgen receptor by effects of dioxin receptor ligand
| Project/Area Number |
26462391
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
篠原 信雄 北海道大学, 医学研究科, 教授 (90250422)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 前立腺癌 / ダイオキシン受容体 / 芳香族炭化水素受容体 / アンドロゲン受容体 / Indirubin |
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| Outline of Final Research Achievements |
The expression status of the dioxin receptor (AhR) in the cell line including the human prostate cancer was confirmed by Western blot analysis. LNCaP, which is known as prostate cancer cell line, proliferation is controlled for indirubin or 3- Methylcholanthrene (3MC) as a typical AhR ligand, and the proliferation potency and the transcriptional ability of these ligands were confirmed, and androgen receptor (AR) appearance has decreased. The concentration dependency was admitted. Nude mice had been administrated these dioxin ligands through peritoneal injection. So, tolerated dose has been becoming clear. As a result, it was thought that the therapeutic gain to the hormone refractory prostate cancer was expected.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Prospective mapping of lymph node metastasis in Japanese patients undergoing radical cystectomy for bladder cancer: characteristics of micrometastasis.2015
Author(s)
Matsumoto R, Takada N, Abe T, Minami K, Harabayashi T, Nagamori S, Hatanaka KC, Miyajima N, Tsuchiya K, Maruyama S, Murai S, Shinohara N
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Journal Title
Japanese journal of clinical oncology
Volume: 45
Pages: 874-880
Related Report
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[Journal Article] Outcome of regional lymphadenectomy in accordance with primary tumor location on laparoscopic nephroureterectomy for urothelial carcinoma of the upper urinary tract: A prospective study2015
Author(s)
Abe T, Takada N, Matsumoto R, Osawa T, Sazawa A, Maruyama S, Tsuchiya K, Harabayashi T, Minami K, Nagamori S, Hatanaka KC, Tanaka Y, Shinohara N, Nonomura K
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Journal Title
Journal of endourology
Volume: 29
Issue: 3
Pages: 304-309
DOI
Related Report
Peer Reviewed
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[Journal Article] Prospective phase II study of image-guided local boost using a real-time tumor-tracking radiotherapy (RTRT) system for locally advanced bladder cancer2014
Author(s)
Nishioka K, Shimizu S, Shinohara N, Ito YM, Abe T, Maruyama S, Kinoshita R, Harada K, Nishikawa N, Miyamoto N, Onimaru R, Shirato H
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Journal Title
Japanese journal of clinical oncology
Volume: 44
Pages: 28-35
NAID
Related Report
Peer Reviewed
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[Journal Article] Early results of urethral dose reduction and small safety margin in intensity-modulated radiation therapy (IMRT) for localized prostate cancer using a real-time tumor-tracking radiotherapy (RTRT) system2014
Author(s)
Shimizu S, Nishioka K, Suzuki R, Shinohara N, Maruyama S, Abe T, Kinoshita R, Katoh N, Onimaru R, Shirato H
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Journal Title
Radiation oncology (London, England)
Volume: 9
Pages: 118-118
NAID
Related Report
Peer Reviewed
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