Ganglioside DSGb5 as a biomarker of prostate cancer
| Project/Area Number |
26462394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tohoku University |
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Principal Investigator |
Satoh Makoto 東北大学, 医学系研究科, 非常勤講師 (70282134)
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| Co-Investigator(Kenkyū-buntansha) |
伊藤 明宏 東北大学, 医学系研究科, 准教授 (70344661)
三塚 浩二 東北大学, 大学病院, 講師 (80568171)
川崎 芳英 東北大学, 医学系研究科, 助教 (80722256)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 泌尿器科学 / 腫瘍学 / 腎癌 / 糖鎖 / ガングリオシド / DSGb5 / 泌尿器科 / 糖鎖抗原 / DSGｂ５ / 泌尿器癌 |
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| Outline of Final Research Achievements |
DSGb5 is a ganglioside originally isolated from tissue extracts of renal cell carcinoma (RCC) with metastasis. In this study, we investigated the clinicopathological significance of DSGb5 expression in RCC and outcomes of RCC patients.
Microvascular invasion was observed in the DSGb5 high expression group. Patients in the DSGb5 high expression group showed significantly lower recurrence-free survival as compared with those in the DSGb5 low expression group. In the present study, DSGb5 expression was associated with microvascular invasion in RCC tissues, and patients with DSGb5 high expression showed significantly lower recurrence-free survival rates. These findings suggest that DSGb5 expressed in RCC is correlated with metastasis and is a potential predictor for identifying patients who experience metastasis after surgery.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Clinicopathological significance of ganglioside DSGb5 expression in renal cell carcinoma.2017
Author(s)
Jun Itoh,Akihiro Ito,Shuichi Shimada,Yoshihide Kawasaki,Narihiko Kakoi,Hideo Saito,Koji Mitsuzuka,Mika Watanabe,Makoto Satoh,Seiichi Saito,Yoichi Arai
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Journal Title
Glycoconjugate Journal
Volume: 34
Pages: 267-273
Related Report
Peer Reviewed / Acknowledgement Compliant
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