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The role of epigenetic change in human testicular germ cell tumors

Research Project

Project/Area Number 26462398
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionUniversity of Tsukuba

Principal Investigator

Kawai Koji  筑波大学, 医学医療系, 講師 (90272195)

Co-Investigator(Kenkyū-buntansha) 末富 崇弘  筑波大学, 医学医療系, 講師 (10574650)
西山 博之  筑波大学, 医学医療系, 教授 (20324642)
市岡 大士  筑波大学, 附属病院, 病院講師 (20712813)
常樂 晃  筑波大学, 医学医療系, 講師 (60436277)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords泌尿器科 / 精巣腫瘍 / エピジェネティクス / セミノーマ / メチル化異常 / DNMT3L
Outline of Final Research Achievements

DNA methyltransferase 3-like (DNMT3L) plays an important role in germ cell development. The aim of this study was to analyse the DNMT3L expression in testicular germ cell tumors(TGCT).
The immunohistochemical expression of DNMT3L was examined in 86 TGCT specimens. DNMT3L expression was observed in all 4 pure yolk sac tumors, of which 3 were prepubertal yolk sac tumors. In mixed GCT. DNMT3L protein was expressed in elements of the embryonal carcinoma (14/18), seminoma (4/11), teratoma (4/7) and choriocarcinoma (3/3) but not in the yolk sac tumors (0/4). When DNMT3L expression was analyzed according to stages, it was significantly correlated with advanced seminoma rather than Stage I seminoma (P = 0.019), And also DNMT3L were expressed not only in embryonic carcinoma cell lines but also in choriocarcinoma. Our findings suggest that DNMT3L may play roles not only in the development of embryonal carcinoma but also in the development of advanced pure seminoma and pure yolk sac tumor.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] DNA methyltransferase-3 like protein expression in various histological types of testicular germ cell tumor.2016

    • Author(s)
      Matsuoka T, Kawai K, Ando S, Sugita S, Kandori S, Kojima T, Miyazaki J, Nishiyama H.
    • Journal Title

      Japanese Journal of Clinical Oncology

      Volume: 46 Issue: 5 Pages: 475-481

    • DOI

      10.1093/jjco/hyw012

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

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