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Intracellular Propionibacterium acnes infection in prostate glands is an independent risk factor for prostate cancer

Research Project

Project/Area Number 26462404
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Eishi Yoshinobu  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70151959)

Research Collaborator KAKEGAWA Tomoya  
TOMII Syohei  
OGAWA Tomohisa  
TAKEMOTO Akira  
KONTA Atsuko  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアクネ菌 / 前立腺癌 / 持続感染 / 前立腺炎 / 新規診断マーカー / 発癌モデル
Outline of Final Research Achievements

Propionibacterium acnes has recently been implicated as a cause of chronic prostatitis and this commensal bacterium may be linked to prostate carcinogenesis. The frequency of P. acnes-positive glands in prostate biopsy samples was higher in PCa samples than in control samples. These results suggested that the frequency of P. acnes-positive glands can be supportive information for urologists in planning repeated biopsy or follow-up strategies. Furthermore, Intracellular P. acnes infection of prostate induced in mice by transurethral inoculation of viable P. acnes induced chronic prostatitis and activates STAT3 in epithelial cells of the P. acnes-infected prostate glands, suggesting that deregulation and inappropriate activation of STAT3 may play a central role in prostate carcinogenesis by P. acnes infection. Further experiments with mice infected in prostate by P. acnes are now in progress and long-term infection may be able to induce prostate cancer in the experimental animals.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2017 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Frequency of Propionibacterium acnes Infection in Prostate Glands with Negative Biopsy Results Is an Independent Risk Factor for Prostate Cancer in Patients with Increased Serum PSA Titers2017

    • Author(s)
      Tomoya Kakegawa, Yuan Bae, Takashi Ito, Keisuke Uchida, Masaki Sekine, Yutaka Nakajima, Asuka Furukawa, Yoshimi Suzuki, Jiro Kumagai, Takumi Akashi, Yoshinobu Eishi
    • Journal Title

      PLOS ONE

      Volume: 12 (1) Issue: 1 Pages: 1-16

    • DOI

      10.1371/journal.pone.0169984

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Intracellular Propionibacterium acnes infection in glandular epithelium and stromal macrophages of the prostate with or without cancer.2014

    • Author(s)
      Bae Y, Ito T, Iida T, Uchida K, Sekine M, Nakajima Y, Kumagai J, Yokoyama T, Kawachi H, Akashi T, Eishi Y.
    • Journal Title

      PLoS One.

      Volume: 28;9(2) Issue: 2 Pages: e90324-e90324

    • DOI

      10.1371/journal.pone.0090324

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 針生検を用いた前立腺癌診断における抗アクネ菌抗体免疫染色の有用性の検討2015

    • Author(s)
      掛川智也、裴有安、伊藤崇、内田佳介、古川あすか、田村玲奈、田村友樹、中嶋裕、関根正喜、明石巧、江石義信
    • Organizer
      第80回日本泌尿器科学会東部総会
    • Place of Presentation
      京王プラザホテル、東京
    • Year and Date
      2015-09-26
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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