| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
Propionibacterium acnes has recently been implicated as a cause of chronic prostatitis and this commensal bacterium may be linked to prostate carcinogenesis. The frequency of P. acnes-positive glands in prostate biopsy samples was higher in PCa samples than in control samples. These results suggested that the frequency of P. acnes-positive glands can be supportive information for urologists in planning repeated biopsy or follow-up strategies. Furthermore, Intracellular P. acnes infection of prostate induced in mice by transurethral inoculation of viable P. acnes induced chronic prostatitis and activates STAT3 in epithelial cells of the P. acnes-infected prostate glands, suggesting that deregulation and inappropriate activation of STAT3 may play a central role in prostate carcinogenesis by P. acnes infection. Further experiments with mice infected in prostate by P. acnes are now in progress and long-term infection may be able to induce prostate cancer in the experimental animals.
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