• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The functional analysis of FABP7, the examination of the triglyceride metabolism and the research to the prevention of renal cell carcinoma

Research Project

Project/Area Number 26462407
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Ozono Seiichiro  浜松医科大学, 医学部, 教授 (00183228)

Co-Investigator(Kenkyū-buntansha) 古瀬 洋  浜松医科大学, 医学部附属病院, 講師 (00345828)
本山 大輔  浜松医科大学, 医学部附属病院, 診療助教 (00727787)
高岡 直央  浜松医科大学, 医学部, 特任研究員 (30467229)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsFABP7 / ドコサテトラエン酸 / EPA / GPD1 / GPD2 / 腎癌 / トリアシルグリセロール生合成系 / 脳型脂肪酸結合タンパク質
Outline of Final Research Achievements

Expression of brain-type fatty acid-binding protein (FABP7) is specifically on renal cell carcinoma (RCC). FABP7 would be worked to stimulation or repression of cell proliferation according to the influence of other factors. It suggests the complicated outbreak mechanism of cancer became clear. In addition, FABP7 has a possibility to be applicable for a treatment target of RCC, because a neoplasia promotion effect was seen by the expression of FABP7. Further, the glycerol-3-phosphate dehydrogenase 1 (GPD1) is on the metabolic pathway that links the triglyceride synthetic pathway to the glycolytic pathway. Expression of GPD1 was weaker in RCC than a kidney tissue. It suggests that GPD1 may be available for the treatment of RCC.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2017 2016 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Functional analysis of fatty acid binding protein 7 and its effect on fatty acid of renal cell carcinoma cell lines.2017

    • Author(s)
      Takaoka N, Takayama T, Ozono S.
    • Journal Title

      BMC Cancer

      Volume: 17 Issue: 1 Pages: 192-199

    • DOI

      10.1186/s12885-017-3184-x

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validity of Tissue Microarray by Immunohistochemistry.2015

    • Author(s)
      Fujita H, Takayama T, Takaoka N, Tan C, Igarashi H, Sugimura H, Ozono S.
    • Journal Title

      Clinical Laboratory

      Volume: 5+6

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] (1)腎癌細胞株での培養が脳型脂肪酸結合タンパク質(FABP7)発現に与える影響2017

    • Author(s)
      高岡 直央、宮崎 美紀、藤田 博美、本山 大輔、松本 力哉、谷島 崇史、鈴木 孝尚、杉山 貴之、大塚 篤史、古瀬 洋、河崎 秀陽、三宅 秀明、大園 誠一郎
    • Organizer
      第26回泌尿器科分子細胞研究会
    • Place of Presentation
      全労済ソレイユ
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腎癌細胞株でのFABP7発現を誘導する培養条件2016

    • Author(s)
      高岡直央、河崎秀陽、宮﨑美紀、藤田博美、大園誠一郎
    • Organizer
      第25回泌尿器科分子・細胞研究会
    • Place of Presentation
      ハイアット リージェンシー大阪
    • Year and Date
      2016-02-26
    • Related Report
      2015 Research-status Report
  • [Presentation] 腎癌細胞株での脳型脂肪酸結合タンパク質(FABP7)が発現する培養条件2016

    • Author(s)
      高岡直央、宮﨑美紀、藤田博美、杉山貴之、古瀬 洋、三宅秀明、大園誠一郞
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腎癌細胞株を用いた脳型脂肪酸結合タンパク質FABP7の機能解析2015

    • Author(s)
      高岡直央、宮﨑美紀、藤田博美、大園誠一郞
    • Organizer
      第46回腎癌研究会
    • Place of Presentation
      品川インターシティホール
    • Year and Date
      2015-07-19
    • Related Report
      2015 Research-status Report
  • [Presentation] 腎癌細胞株を用いた脂肪酸結合蛋白質7の解析2014

    • Author(s)
      高岡 直央、藤田 博美、宮崎 美紀、杉山 貴之、古瀬 洋、大園 誠一郎
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi