Molecular mechanisms of ligand-independent androgen receptor activation in development and progression of prostate cancer
Project/Area Number |
26462408
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Mie University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
神田 英輝 三重大学, 医学部附属病院, 講師 (10397507)
佐々木 豪 三重大学, 医学部附属病院, 医員 (20644941)
白石 泰三 三重大学, 医学系研究科, 客員教授 (30162762)
石井 健一朗 三重大学, 医学系研究科, 助教 (90397513)
加藤 学 三重大学, 医学部附属病院, 助教 (60626117)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 前立腺癌 / 癌関連線維芽細胞 / アンドロゲン受容体 / 前立腺特異抗原 / 前立腺癌間質標的療法 / 癌間質線維芽細胞 |
Outline of Final Research Achievements |
Tumor stroma surrounding prostate cancer (PCa) cells is enriched in fibroblasts secreting androgen receptor (AR)-activating factors. Thus, fibroblast-dependent AR activation in PCa cells under androgen deprivation therapy (ADT) may play an important role in progression of castration-resistant prostate cancer (CRPC). In this study, we investigated the role of fibroblasts in AR activation of PCa cells differing in androgen sensitivity. In the condition of co-cultures with fibroblasts, PSA production was directly increased in E9 cells but not in F10 and AIDL cells. In E9 cells + pcPrF-M5 group, tumor growth became diminished post ADT but serum PSA was gradually increased even post ADT. Here our results have demonstrated that fibroblast-dependent AR activation under ADT showed diverse effects in PCa cells differing in androgen sensitivity. In a certain androgen-low-sensitive PCa cells, fibroblast-dependent AR activation may progress to CRPC.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Low serum dehydroepiandrosterone examined by liquid chromatography-tandem mass spectrometry correlates with poor prognosis in hormone-naïve prostate cancer.2016
Author(s)
Miyoshi Y, Uemura H, Umemoto S, Sakamaki K, Taguri M, Suzuki K, Shibata Y, Masumori N, Ichikawa T, Mizokami A, Sugimura Y, Nonomura N, Sakai H, Honma S, Harada M, Kubota Y.
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Journal Title
Prostate
Volume: 76
Issue: 4
Pages: 376-382
DOI
Related Report
Peer Reviewed
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[Journal Article] High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients.2014
Author(s)
Miyoshi Y, Uemura H, Umemoto S, Sakamaki K, Morita S, Suzuki K, Shibata Y, Masumori N, Ichikawa T, Mizokami A, Sugimura Y, Nonomura N, Sakai H, Honma S, Harada M, Kubota Y.
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Journal Title
BMC Cancer
Volume: Sep 26
Issue: 1
Pages: 717-717
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] The exploration of the order in the heterogeneity of prostate cancer-associated stroma environment2016
Author(s)
Manabu Kato, Takeshi Sasaki, Kenichiro Ishii, Manabu Miki, Kohei Nishikawa, Kiminobu Arima, Taizo Shiraishi, Neil Bhowmick, Yoshiki Sugimura
Organizer
111st American Urological Association Annual meeting
Place of Presentation
San Diego, CA, USA
Year and Date
2016-05-06
Related Report
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