Regulatory T cells in intravesical BCG therapy for non-muscle invasive bladder cancer
| Project/Area Number |
26462409
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
花田 英紀 滋賀医科大学, 医学部, 助教 (40555067)
影山 進 滋賀医科大学, 医学部, 講師 (50378452)
吉貴 達寛 滋賀医科大学, 医学部, 客員教授 (80230704)
河内 明宏 滋賀医科大学, 医学部, 教授 (90240952)
村井 亮介 滋賀医科大学, 医学部, 医員 (80748583)
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| Co-Investigator(Renkei-kenkyūsha) |
OGASAWARA Kazumasa 滋賀医科大学, 医学部, 教授 (20169163)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 制御性T細胞 / 膀胱癌 / BCG |
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| Outline of Final Research Achievements |
We investigated the affection of regulatory T cells in recurrence of bladder cancer. From analysis of 105 cases of non-muscle invasive bladder cancer, patients with high Treg invasion in the tumor had high intravesical recurrence rate. Similar results were found in the group treated with intravesical BCG. Therefore, we considered that regulatory T cells may affect to recurrence and progression of bladder cancer. Next, to investigate how regulatory T cells work with intravesical BCG therapy for bladder cancer, we evaluated the change of regulatory T cells among intravesical BCG therapy using a rat bladder cancer model. Tregs in the peripheral blood tended to be higher in the intravesical BCG treatment group than in the control group. We continue the treatment experiment combined intravesical BCG and Treg-adsorbing hemodialysis.
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Report
(4 results)
Research Products
(2 results)
