| Project/Area Number |
26462415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagasaki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
望月 保志 長崎大学, 病院(医学系), 講師 (40404256)
宮田 康好 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (60380888)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 泌尿器癌 / 表在性膀胱癌 / HO-1 / 腎細胞癌 / 免疫染色 |
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| Outline of Final Research Achievements |
The present study investigated the association between HO-1 expression levels and the pathological features, clinical outcomes and other associated factors in patients with non-muscle-invasive bladder cancer (NMIBC). HO-1 expression levels in high-grade and pT1 tumors were significantly higher compared with low-grade and pTa tumors, and were correlated with the proliferation index, lymph vessel density and COX-2 expression levels. Kaplan-Meier survival curves associated HO-1 expression with a poor prognosis in metastasis-free and cause-specific survival. Furthermore, HO-1 expression was identified by multivariate analysis to be a significant predictor for cause-specific survival. HO-1-associated activities are regulated by cancer cell proliferation, lymphangiogenesis and COX-2. HO-1 may be a potential therapeutic target and a useful predictive prognostic factor in patients with NMIBC.
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