Study for elucidating tumor suppressive microRNA that has anti proliferation and prevent metastasis by using metastasis model mouse in bladder cancer
Project/Area Number |
26462416
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Urology
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Research Institution | Kagoshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
関 直彦 千葉大学, 大学院医学研究院, 准教授 (50345013)
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Co-Investigator(Renkei-kenkyūsha) |
KATAOKA Kazunori 東京大学, 疾患生命工学センター, 教授 (00130245)
MIYATA Kanjiro 東京大学, 疾患生命工学センター, 准教授 (50436523)
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Research Collaborator |
INOGUCHI Satoru 鹿児島大学, 医歯学総合研究科, 大学院生
ISHIHARA Tomoaki 鹿児島大学, 医歯学総合研究科, 大学院生
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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Keywords | マイクロRNA / 膀胱癌 / microRNA / ナノミセル |
Outline of Final Research Achievements |
Based on the microRNAs expression profile by next generation sequencing in bladder cancer, we identified several tumor suppressive microRNAs including miR-144-5p/3p and miR-23b/24/27b and found their target tumor-associated genes such as c-MET, EGFR involved in important cancer signaling pathway or cyclin E1/E2 involved in cell cycle. MicroRNA-based studies revealed novel cancer biology. We are planning in vivo study following these results.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Dual regulation of receptor tyrosine kinase genes EGFR and c-Met by the tumor-suppressive microRNA-23b/27b cluster in bladder cancer.2015
Author(s)
Chiyomaru T, Seki N, Inoguchi S, Ishihara T, Mataki H, Matsushita R, Goto Y, Nishikawa R, Tatarano S, Itesako T, Nakagawa M, Enokida H.
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Journal Title
International Journal of Oncology
Volume: 46
Issue: 2
Pages: 487-496
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Tumour-suppressive microRNA-24-1 inhibits cancer cell proliferation through targeting FOXM1 in bladder cancer.2014
Author(s)
Inoguchi S, Seki N, Chiyomaru T, Ishihara T, Matsushita R, Mataki H, Itesako T, Tatarano S, Yoshino H, Goto Y, Nishikawa R, Nakagawa M, Enokida H.
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Journal Title
FEBS letter
Volume: 588
Issue: 17
Pages: 3170-3179
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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