| Project/Area Number |
26462416
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
関 直彦 千葉大学, 大学院医学研究院, 准教授 (50345013)
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| Co-Investigator(Renkei-kenkyūsha) |
KATAOKA Kazunori 東京大学, 疾患生命工学センター, 教授 (00130245)
MIYATA Kanjiro 東京大学, 疾患生命工学センター, 准教授 (50436523)
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| Research Collaborator |
INOGUCHI Satoru 鹿児島大学, 医歯学総合研究科, 大学院生
ISHIHARA Tomoaki 鹿児島大学, 医歯学総合研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | マイクロRNA / 膀胱癌 / microRNA / ナノミセル |
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| Outline of Final Research Achievements |
Based on the microRNAs expression profile by next generation sequencing in bladder cancer, we identified several tumor suppressive microRNAs including miR-144-5p/3p and miR-23b/24/27b and found their target tumor-associated genes such as c-MET, EGFR involved in important cancer signaling pathway or cyclin E1/E2 involved in cell cycle. MicroRNA-based studies revealed novel cancer biology. We are planning in vivo study following these results.
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