Effect of androgen deprivation therapy on bladder cancer recurrence

• Project/Area Number: 26462419
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: IZUMI Koji 横浜市立大学, 医学研究科, 客員研究員 (00721531)
• Co-Investigator(Kenkyū-buntansha): 上村 博司 横浜市立大学, 附属市民総合医療センター, 准教授 (50244439)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 膀胱癌 / アンドロゲン / アンドロゲンレセプター / 抗アンドロゲン療法 / 膀胱がん

Outline of Final Research Achievements

We investigated effect of androgen deprivation therapy (ADT) for prostate cancer (PC) on bladder cancer (BC) recurrence. We reviewed 20,328 patients with prostate cancer (PC) and identified 239 bladder cancer (BC). 162 patients made up the final cohort and 86 patients received ADT and 76 patients did not. 5-year recurrence-free survival (RFS) of BC was 40% in no-ADT patients and 76% in ADT patients. In multivariate analysis, ADT was an independent prognosticator for BC recurrence and its hazard ratio was 0.29. Since most of the ADT patients received luteinizing hormone-releasing hormone which deprives estrogens as well as androgens, we investigated expressions of androgen receptor (AR)/ estrogen receptor (ER)α/ERβ in ADT patients. Although AR expression significantly correlated with better RFS, ERα/ERβ expression showed no correlation with BC recurrence. These results suggest the preventive effect of ADT on BC recurrence is mediated by AR but not ERα/ERβ signal.

Research Products

• [Int'l Joint Research] Johns Hopkins University(米国)
• [Journal Article] Expression of androgen receptor in non-muscle-invasive bladder cancer predicts the preventive effect of androgen deprivation therapy on tumor recurrence. (2016)
  • Author(s): Izumi K, Ito Y, Miyamoto H, Miyoshi Y, Ota J, Moriyama M, Murai T, Hayashi H, Inayama Y, Ohashi K, Yao M, Uemura H.
  • Journal Title: Oncotarget Volume: 1 Issue: 12 Pages: 1-8
  • DOI: 10.18632/oncotarget.7358
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Androgen deprivation therapy prevents bladder cancer recurrence. (2014)
  • Author(s): Izumi K, Taguri M, Miyamoto H, Hara Y, Kishida T, Chiba K, Murai T, Hirai K, Suzuki K, Fujinami K, Ueki T, Udagawa K, Kitami K, Moriyama M, Miyoshi Y, Tsuchiya F, Ikeda I, Kobayashi K, Sato M, Morita S, Noguchi K, and Uemura H.
  • Journal Title: Oncotarget Volume: 5 Pages: 12665-74
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] UDP-glucuronosyltransferase 1A (UGT1A) immunohistochemistry in urothelial carcinoma of the upper urinary tract as a strong prognosticator. (2016)
  • Author(s): Koji Izumi
  • Organizer: American Urological Association Annual meeting 2016
  • Place of Presentation: San Diego, USA
  • Year and Date: 2016-05-06
  • Int'l Joint Research
• [Presentation] Expression of androgen receptor in non-muscle-invasive bladder cancer predicts the preventive effect of androgen deprivation therapy on tumor recurrence (2015)
  • Author(s): Koji Izumi, Yusuke Ito, Hiroshi Miyamoto, Yasuhide Miyoshi, Junichi Ota, Masatoshi Moriyama, Tetsuo Murai, Hiroyuki Hayashi, Yoshiaki Inayama, Kenichi Ohashi, Masahiro Yao and Hiroji Uemura
  • Organizer: 7th European Multidisciplinary Meeting on Urological Cancers
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2015-11-12
  • Int'l Joint Research
• [Presentation] Androgen Deprivation Therapy (ADT) Prevents Recurrence of Bladder Cancer (2015)
  • Author(s): Koji Izumi, Masataka Taguri, Hiroshi Miyamoto, Yusuke Ito, Yasuhide Miyoshi, Masatoshi Moriyama, Tetsuo Murai, Hiroyuki Hayashi, Yoshiyuki Inayama, Yoji Nagashima, Satoshi Morita, Hiroji Uemura
  • Organizer: American Urological Association annual meeting 2015
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2015-05-15
  • Int'l Joint Research
• [Presentation] Androgen Deprivation Therapy Prevents Recurrence of Bladder Cancer. (2015)
  • Author(s): Koji Izumi, Masataka Taguri, Hiroshi Miyamoto, Yusuke Ito, Yasuhide Miyoshi, Masatoshi Moriyama, Tetsuo Murai, Hiroyuki Hayashi, Yoshiyuki Inayama, Yoji Nagashima, Satoshi Morita, Hiroji Uemura
  • Organizer: American Urological Association Annual meeting 2015
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2015-05-14 – 2015-05-19
• [Presentation] 膀胱癌におけるAR発現は抗アンドロゲン療法による膀胱癌再発抑制効果を予測する (2015)
  • Author(s): 泉 浩司、伊藤 悠亮、森山 正敏、三好 康秀、村井 哲夫、林 宏行、 稲山 嘉明、長嶋 洋治、宮本 浩、野口 和美、矢尾 正祐、上村 博司
  • Organizer: 第103回日本泌尿器科学会総会
  • Place of Presentation: ホテル日航金沢（石川県金沢市）
  • Year and Date: 2015-04-18
• [Presentation] Androgen Deprivation Therapy Prevents Recurrence of Bladder Cancer. (2015)
  • Author(s): Koji Izumi, Masataka Taguri, Hiroshi Miyamoto, Yusuke Ito, Yasuhide Miyoshi, Masatoshi Moriyama, Tetsuo Murai, Hiroyuki Hayashi, Yoshiyuki Inayama, Yoji Nagashima, Satoshi Morita, Hiroji Uemura
  • Organizer: European Association of Urology Annual meeting 2015
  • Place of Presentation: Madrid, Spain
  • Year and Date: 2015-03-20 – 2015-03-24
• [Presentation] The Impact of Androgen Deprivation Therapy on Bladder Cancer Recurrence. (2014)
  • Author(s): Koji Izumi, Masataka Taguri, Hiroshi Miyamoto, Maho Sato, Satoshi Morita ,Hiroji Uemura
  • Organizer: The 6th Annual Meeting of European Multidiciplinary Meeting on Urologic Caners
  • Place of Presentation: Lisbon, Prtugal
  • Year and Date: 2014-11-13 – 2014-11-16
• [Presentation] 前立腺癌症例におけるホルモン療法は膀胱癌の再発を抑制する (2014)
  • Author(s): 泉 浩司、上村 博司、矢尾 正祐、中井川 昇、槙山 和秀、林 成彦、逢坂 公人、横溝 由美子、古屋 一裕、今野 真思、三留 拓、宮本 浩、窪田 吉信
  • Organizer: 第102回日本泌尿器科学会総会
  • Place of Presentation: 神戸国際会議場（兵庫県神戸市）
  • Year and Date: 2014-04-24 – 2014-04-27
• [Book] 次世代のがん治療薬・診断のための研究開発 (2016)
  • Author(s): 泉 浩司
  • Total Pages: 6
  • Publisher: 技術情報協会
• [Book] 臨床泌尿器科 (2016)
  • Author(s): 泉 浩司、澤田 卓人、太田 純一
  • Total Pages: 7
  • Publisher: 医学書院
• [Remarks] 横浜市立大学 先端医科学研究センター
  • URL: http://www.yokohama-cu.ac.jp/amedrc/res/uemura_201412.html
• [Remarks] 科学技術振興機構(JST)サイエンスポータル
  • URL: http://scienceportal.jst.go.jp/news/newsflash_review/newsflash/2015/01/20150108_03.html