Analysis of functional RNA networks and investigation of their target genes in castration-resistant prostate cancer (CRPC).
| Project/Area Number |
26462430
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Teikyo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
関 直彦 千葉大学, 大学院医学研究院, 准教授 (50345013)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 前立腺癌 / マイクロRNA / 発現プロファイル / 去勢抵抗性 / 遺伝子解析 / 癌抑制遺伝子 / 去勢抵抗性前立腺癌 / ゲノムシークエンス / マイクロＲＮＡ / 転移 / 浸潤 / ゲノム |
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| Outline of Final Research Achievements |
The expression levels of miR-452 was decreased in castration-resistant prostate cancer (CRPC), and the transfection of miR-452 induced repression of cell migration and invasion in PC3 and Du145 cells. One of the target genes is E3 ubiquitin ligase-1 (WWP1). Knock-down of expression levels of WWP1 induced repression of cell migration and invasion in PC3 and Du145 cells, indicated WWP1 is an oncogene. CRPC patients with lower levels of miR-452 showed short duration of time to CRPC after androgen depletion therapy. miR-452 is a prognostic factor of progressed prostate cancer and targeting WWP1 expression might be a possible treatment for CRPC.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] The microRNA signature of patients with sunitinib failure: regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma.2016
Author(s)
Goto Y, Kurozumi A, Nohata N, Kojima S, Matsushita R, Yoshino H, Yamazaki K, Ishida Y, Ichikawa T, Naya Y, Seki N.
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Journal Title
Oncotarget
Volume: 7
Issue: 37
Pages: 59070-59086
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker.2015
Author(s)
Goto Y, Kojima S, Nishikawa R, Kurozumi A, Kato M, Enokida H, Matsushita R, Yamazaki K, Ishida Y, Nakagawa M, Naya Y, Ichikawa T, Seki N
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Journal Title
Br J Cancer
Volume: 113
Issue: 7
Pages: 1055-1065
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] The tumor-suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOLM1 in prostate cancer.2014
Author(s)
Kojima S, Enokida H, Yoshino H, Itesako T, Chiyomaru T, Kinoshita T, Fuse M, Nishikawa R, Goto Y, Naya Y, Nakagawa M, Seki N.
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Journal Title
J Hum Genet.
Volume: 59(2)
Issue: 2
Pages: 78-87
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumour-suppressive microRNA-224 inhibits cancer cell migration and invasion via targeting oncogenic TPD52 in prostate cancer.2014
Author(s)
Goto Y, Nishikawa R, Kojima S, Chiyomaru T, Enokida H, Inoguchi S, Kinoshita T, Fuse M, Sakamoto S, Nakagawa M, Naya Y, Ichikawa T, Seki N.
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Journal Title
FEBS Lett.
Volume: 588(10)
Issue: 10
Pages: 1973-1982
DOI
Related Report
Peer Reviewed
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[Journal Article] 1. Tumor-suppressive microRNA-29s inhibit cancer cell migration and invasion via2014
Author(s)
Nishikawa R, Goto Y, Kojima S, Enokida H, Chiyomaru T, Kinoshita T, Sakamoto S, Fuse M, Nakagawa M, Naya Y, Ichikawa T, Seki N
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Journal Title
Int J Oncol.
Volume: 45(1)
Issue: 1
Pages: 401-410
DOI
Related Report
Peer Reviewed
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[Journal Article] Tumor-suppressive microRNA-218 inhibits cancer cell migration and invasion via targeting of LASP1 in prostate cancer.2014
Author(s)
Nishikawa R, Goto Y, Sakamoto S, Chiyomaru T, Enokida H, Kojima S, Kinoshita T, Yamamoto N, Nakagawa M, Naya Y, Ichikawa T, Seki N.
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Journal Title
Cancer Sci
Volume: 105
Issue: 7
Pages: 802-811
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Identification of dual tumorsuppressors (miR-225p/miR-223p) based on microRNA expression signature by deep sequencing of CRPC.2016
Author(s)
Yusuke Goto, Satoko Kojima, Akira Kurozumi, Mayuko Kato, Atsushi Okato, Yukio Naya, Hideki Enokida, Ryosuke Matsushita, Masayuki Nakagawa, Tomohiko Ichikawa, Naohiko Seki.
Organizer
American Urology Association
Place of Presentation
San Diego (USA)
Year and Date
2016-05-06
Related Report
Int'l Joint Research
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[Presentation] Regulation of UHRF1mediated pathways by tumorsuppressive microRNA101 in molecular targeted therapy resistant renal cell carcinoma.2016
Author(s)
Yusuke Goto, Akira Kurozumi, Mayuko Kato, Atsushi Okato, Satoko Kojima, Ryosuke Matsushita, Hirofumi Yoshino, Hideki Enokida, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki.
Organizer
American Urology Association
Place of Presentation
San Diego (USA)
Year and Date
2016-05-06
Related Report
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[Presentation] Targeting multiple functions of E3 ubiquitin ligase-1 (WWP1) signaling by miR-452 inhibits cancer cell migration and invasion in prostate cancer.2015
Author(s)
Yusuke Goto, Akira Kurozumi, Rika Nishikawa, Mayuko Kato, Shinichi Sakamoto, Satoko Kojima, Yukio Naya, Hideki Enokida, Masayuki Nakagawa, Tomohiko Ichikawa, Naohiko Seki.
Organizer
AUA 2015 （米国泌尿器科学会）
Place of Presentation
ニューオーリンズ（アメリカ合衆国）
Year and Date
2015-05-15
Related Report
Int'l Joint Research
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[Presentation] Tumour suppressive microRNA-143/145 cluster inhibits cell migration and invasion by targeting GOKM1 in prostate cancer2014
Author(s)
S.Kojima, H.Enomoto, H.Yoshino, T.Itesako, T.Chiyomaru, T.Kinoshita, M.Fuse, Y.Goto, R.Nishikawa, Y.Naya, M.Nakagawa, N Seki
Organizer
29th Annual EAU Congress
Place of Presentation
Stockholm(ｽｳｪｰﾃﾞﾝ）
Year and Date
2014-04-11 – 2014-04-15
Related Report
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