| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Outline of Final Research Achievements |
The expression levels of miR-452 was decreased in castration-resistant prostate cancer (CRPC), and the transfection of miR-452 induced repression of cell migration and invasion in PC3 and Du145 cells. One of the target genes is E3 ubiquitin ligase-1 (WWP1). Knock-down of expression levels of WWP1 induced repression of cell migration and invasion in PC3 and Du145 cells, indicated WWP1 is an oncogene. CRPC patients with lower levels of miR-452 showed short duration of time to CRPC after androgen depletion therapy. miR-452 is a prognostic factor of progressed prostate cancer and targeting WWP1 expression might be a possible treatment for CRPC.
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