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Role of bioactive oxidized lipid in urothelial carcinoma

Research Project

Project/Area Number 26462431
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionNippon Medical School

Principal Investigator

Kondo Yukihiro  日本医科大学, 大学院医学研究科, 大学院教授 (80215467)

Co-Investigator(Kenkyū-buntansha) 鈴木 康友  日本医科大学, 医学部, 准教授 (90297911)
齋藤 友香  日本医科大学, 医学部, 助教 (60350063)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords尿路上皮癌 / 生理活性酸化脂質 / シスプラチン / ホスホリパーゼ2 / 膀胱腫瘍 / 低酸素応答 / プロスタグランジン / 新規生理酸化脂質 / 血管新生 / アラキドン酸
Outline of Final Research Achievements

Regarding the treatment of urothelial carcinoma, besides surgical therapy, besides radiotherapy and cisplatin-based chemotherapy, there is currently no choice. Therefore, it is important to develop new treatments or to expand the effect of existing treatments. This study focused on phospholipase 2, an enzyme that liberates fatty acids and lysophospholipids to increase the therapeutic effect of cisplatin. Among them, calcium-independent phospholipase 2 was found to be involved in the suppression of proliferation of bladder cancer cells. Therefore, we discovered that the inhibitor of calcium-independent phospholipase 2 and cisplatin are used in combination to obtain a higher effect. We are currently studying for clinical application.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2017 2015

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Role of prostacyclin synthase in carcinogenesis2017

    • Author(s)
      Sasaki Y, Ochiai T, Takamura M, Kondo Y, Yokoyama C, Hara S.
    • Journal Title

      Prostaglandins and Other Lipid Mediator

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Advantage of a Ureteroscopic Navigation System with Magnetic Tracking in Comparison with Simulated Fluoroscopy in a Phantom Study.2015

    • Author(s)
      Yoshida K, Yokomizo A, Matsuda T, Hamasaki T, Kondo Y, Yamaguchi K, Kanayama HO, Wakumoto Y, Horie S, Naito S.
    • Journal Title

      J Endourol.

      Volume: 7 Pages: 223-227

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Efficacy of a thermoexpandable metallic prostate stent (Memokath) in elderly patients with urethral obstruction requiring long-term management with urethral Foley catheters.2015

    • Author(s)
      Kimata R, Nemoto K, Tomita Y, Takahashi R, Hamasaki T, Kondo Y.
    • Journal Title

      Geriatr Gerontol Int.

      Volume: 15(5) Issue: 5 Pages: 553-558

    • DOI

      10.1111/ggi.12309

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 膀胱癌に対するシスプラチン(CDDP)の癌増殖抑制とiPLA2γ(カルシウム非依存性PLA2γ)の関与について2017

    • Author(s)
      中山聡子、鈴木康友、原俊太郎、近藤幸尋
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      鹿児島市
    • Year and Date
      2017-04-21
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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