| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Female Sprague-Dawley rats were used in this study. The effect of unilateral electrical stimulation (ES) on neurogenic storage dysfunction model was investigated. We used two models of neurogenic storage dysfunction. Cerebral infarction (CI) model was made by an unilateral embolization of middle cerebral artery, and spinal cord injury (SCI) model was made by a transection of spinal cord at the level of T 7/8. Stimulation was set as 5 Hz and 200 μsec bipolar pulse wave according to the previous study. Peripheral somatic nerve was stimulated via a cuff electrode implanted around the left tibial nerve. Cystometric study revealed no significant changes in spite of the initiation of ES. Therefore, we did not investigate neurotransmitters and gene expression concerning neuronal plasticity.
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