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Study on effects of bushi for opioid receptor Kappa type of bladder pain model

Research Project

Project/Area Number 26462439
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Urology
Research InstitutionUniversity of Yamanashi

Principal Investigator

TSUCHIDA Takayuki  山梨大学, 総合研究部, 医学研究員 (30217327)

Co-Investigator(Renkei-kenkyūsha) MIYAMOTO Tatsuya  山梨大学, 総合研究部, 助教 (80456459)
KOBAYASHI Hideki  山梨大学, 総合研究部, 講師 (50402053)
ZAKOUJI Hidenori  山梨大学, 総合研究部, 准教授 (60345717)
TAKEDA Masayuki  山梨大学, 総合研究部, 教授 (80197318)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsブシ / ナルフラフィン塩酸塩 / κオピオイド / 膀胱痛 / オピオイド受容体κ型 / 漢方 / 間質性膀胱炎 / 附子末 / 神経障害性疼痛 / 下降抑制系
Outline of Final Research Achievements

o determine the effect using the κ-opioid receptor antagonist medication norvinaltorphimine is administered in the treatment group compared to. Also considering the comparison with nalfurafine hydrochloride administered as a κ-receptor-selective cholinergic drug group. Capacity of the "Bush" effect was verified in experiments for nalfurafine hydrochloride, consider "bushy," examined various capacities, but did not statistically significant results. Sliding plate "busy" system and the nalfurafine system which is difficult. May we at least use "busy" and nalfurafine hydrochloride than single use further affect the opioid receptor-type and expected future development.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015

All Presentation (1 results) (of which Invited: 1 results) Book (1 results)

  • [Presentation] ブシ(附子)を含んだ漢方の膀胱痛に対する作用機序の基礎的解明と臨床的検討2015

    • Author(s)
      土田孝之
    • Organizer
      日本泌尿器科学会総会
    • Place of Presentation
      石川県立音楽堂(石川県・金沢市)
    • Year and Date
      2015-04-19
    • Related Report
      2015 Research-status Report 2014 Research-status Report
    • Invited
  • [Book] Science of Kampo Medicine2015

    • Author(s)
      土田孝之
    • Total Pages
      3
    • Publisher
      臨床情報センター
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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