Study on effects of bushi for opioid receptor Kappa type of bladder pain model
| Project/Area Number |
26462439
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMOTO Tatsuya 山梨大学, 総合研究部, 助教 (80456459)
KOBAYASHI Hideki 山梨大学, 総合研究部, 講師 (50402053)
ZAKOUJI Hidenori 山梨大学, 総合研究部, 准教授 (60345717)
TAKEDA Masayuki 山梨大学, 総合研究部, 教授 (80197318)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ブシ / ナルフラフィン塩酸塩 / κオピオイド / 膀胱痛 / オピオイド受容体κ型 / 漢方 / 間質性膀胱炎 / 附子末 / 神経障害性疼痛 / 下降抑制系 |
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| Outline of Final Research Achievements |
o determine the effect using the κ-opioid receptor antagonist medication norvinaltorphimine is administered in the treatment group compared to. Also considering the comparison with nalfurafine hydrochloride administered as a κ-receptor-selective cholinergic drug group. Capacity of the "Bush" effect was verified in experiments for nalfurafine hydrochloride, consider "bushy," examined various capacities, but did not statistically significant results. Sliding plate "busy" system and the nalfurafine system which is difficult. May we at least use "busy" and nalfurafine hydrochloride than single use further affect the opioid receptor-type and expected future development.
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Report
(4 results)
Research Products
(2 results)
