Establishment of the effective treatment for gonococcal pharygeal infection

• Project/Area Number: 26462442
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Gifu University
• Principal Investigator: YASUDA Mitsuru 岐阜大学, 医学部附属病院, 講師 (90311703)
• Co-Investigator(Kenkyū-buntansha): 出口 隆 岐阜大学, 大学院医学系研究科, 教授 (40163935)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 淋菌咽頭感染 / 薬剤耐性淋菌 / セフトリアキソン耐性 / アジスロマイシン耐性 / 淋菌 / 薬剤耐性 / 咽頭感染

Outline of Final Research Achievements

We examined antimicrobial susceptibilities of Neisseria gonorrhoeae (total 2,787 clinical strains: 94 strains isolated from pharynx, 2,608 strains from urethra and 85 strains from cervix). Only ceftriaxone and spectinomycin have high antimicrobial activities against N. gonorrhoeae. Azithromycin is not recommended for treatment against gonococcal infections because the efficacy of azithromycin for gonococcal urethritis was decreased in Sendai. Moreover spectinomycin is not used to treat pharyngeal infection because of low tissue penetration. Therefore it is thought that ceftriaxone is effective to treat gonococcal pharyngeal infection from these results. In fact, ceftriaxone 1g single dose that is recommended in Japanese guideline have 51.48 hours of “Therapeutic time”. It is thought that ceftriaxone 1g single dose is effective to treat gonococcal pharyngeal infection because therapeutic time of this dose is over 30 hours that is >95% expected cure rate in pharyngeal infection.

Research Products

• [Journal Article] Antimicrobial Susceptibility of Neisseria gonorrhoeae in Japan from 2000 to 2015. (2017)
  • Author(s): Yasuda M, Hatazaki K, Ito S, Kitanohara M, Yoh M, Kojima M, Narita H, Kido A, Miyata K, Deguch T.
  • Journal Title: Sexually Transmitted Diseses Volume: 44 Issue: 3 Pages: 149-153
  • DOI: 10.1097/olq.0000000000000556
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Haemophilus influenzae Isolated From Men With Acute Urethritis: Its Pathogenic Roles, Responses to Antimicrobial Chemotherapies, and Antimicrobial Susceptibilities. (2017)
  • Author(s): Ito S, Hatazaki K, Shimuta K, Kondo H, Mizutani K, Yasuda M, Nakane K, Tsuchiya T, Yokoi S, Nakano M, Ohinishi M, Deguchi T.
  • Journal Title: Sexually Transmitted Diseses Volume: 44 Issue: 4 Pages: 205-210
  • DOI: 10.1097/olq.0000000000000573
  • Peer Reviewed
• [Journal Article] Novel penA mutations identified in Neisseria gonorrhoeae with decreased susceptibility to ceftriaxone isolated between 2000 and 2014 in Japan (2016)
  • Author(s): J Antimicrob Chemother
  • Journal Title: J Antimicrob Chemother Volume: 71 Issue: 9 Pages: 2466-2470
  • DOI: 10.1093/jac/dkw161
  • Peer Reviewed
• [Journal Article] Male non-gonococcal urethritis: From microbiological etiologies to demographic and clinical features. (2016)
  • Author(s): Ito S, Hanaoka N, Shimuta K, Seike K, Tsuchiya T, Yasuda M, Yokoi S, Nakano M, Ohnishi M, Deguchi T.
  • Journal Title: Int J Urol Volume: 23(4) Issue: 4 Pages: 325-31
  • DOI: 10.1111/iju.13044
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis (2016)
  • Author(s): Ito S, Yasuda M, Hatazaki K, Mizutani K, Tsuchiya T, Yokoi S, Nakano M, Deguchi T
  • Journal Title: J Antimicrob Chemother Volume: 71 Issue: 9 Pages: 2559-2562
  • DOI: 10.1093/jac/dkw180
  • Peer Reviewed
• [Journal Article] Remarkable increase of Neisseria gonorrhoeae with decreased susceptibility of azithromycin and increase in the failure of azithromycin therapy in male gonococcal urethritis in Sendai in 2015. (2016)
  • Author(s): Yasuda M, Ito S, Hatazaki K, Deguchi T.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 22 Issue: 12 Pages: 841-843
  • DOI: 10.1016/j.jiac.2016.07.012
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Japanese guideline for clinical research of antimicrobial agents on urogenital infections: second edition. (2016)
  • Author(s): Yasuda M, Muratani T, Ishikawa K, Kiyota H, Sakata H, Shigemura K, Takahashi S, Hamasuna R, Hayami H, Mikamo H, Yamamoto S, Watanabe T, Arakawa S.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 22 Issue: 10 Pages: 651-661
  • DOI: 10.1016/j.jiac.2016.07.018
  • Peer Reviewed
• [Journal Article] Multidrug-Resistant Mycoplasma genitalium Is Increasing. (2016)
  • Author(s): Deguchi T, Kikuchi M, Yasuda M, Ito S.
  • Journal Title: Clinical infectious diseases Volume: 62 Issue: 3 Pages: 405-406
  • DOI: 10.1093/cid/civ898
  • Peer Reviewed
• [Journal Article] New Clinical Strain of Neisseria gonorrhoeae with Decreased Susceptibility to Ceftriaxone, Japan. (2016)
  • Author(s): Deguchi T, Yasuda M, Hatazaki K, Kameyama K, Horie K, Kato T, Mizutani K, Seike K, Tsuchiya T, Yokoi S, Nakano M, Yoh M.
  • Journal Title: Emerging infectious diseases Volume: 22 Issue: 1 Pages: 142-144
  • DOI: 10.3201/eid2201.150868
  • Peer Reviewed / Open Access
• [Journal Article] Drug resistance-associated mutations in Mycoplasma genitalium in female sex workers, Japan. (2015)
  • Author(s): Deguchi T, Yasuda M, Horie K, Seike K, Kikuchi M, Mizutani K, Tsuchiya T, Yokoi S, Nakano M, Hoshina S.
  • Journal Title: Emerging infectious diseases Volume: 21 Issue: 6 Pages: 1062-1064
  • DOI: 10.3201/eid2106.142013
  • Peer Reviewed / Open Access
• [Journal Article] Re: Adrian Pilatz, Hamid Hossain, Rolf Kaiser, et al. Acute epididymitis revisited: impact of molecular diagnostics on etiology and contemporary guideline recommendations. (2015)
  • Author(s): Deguchi T, Yasuda M, Ito S.
  • Journal Title: European urology Volume: 68 Issue: 3 Pages: 428-435
  • DOI: 10.1016/j.eururo.2015.03.045
  • Peer Reviewed
• [Journal Article] Bacterial loads of Ureaplasma parvum contribute to the development of inflammatory responses in the male urethra. (2015)
  • Author(s): Deguchi T, Shimada Y, Horie K, Mizutani K, Seike K, Tsuchiya T, Yokoi S, Yasuda M, Ito S.
  • Journal Title: International journal of STD & AIDS Volume: 26 Issue: 14 Pages: 1035-1039
  • DOI: 10.1177/0956462414565796
  • Peer Reviewed
• [Journal Article] Sitafloxacin: antimicrobial activity against ciprofloxacin-selected laboratory mutants of Mycoplasma genitalium and inhibitory activity against its DNA gyrase and topoisomerase IV. (2015)
  • Author(s): Deguchi T, Kikuchi M, Yasuda M, Ito S.
  • Journal Title: Journal of infection and chemotherapy Volume: 21 Issue: 1 Pages: 74-75
  • DOI: 10.1016/j.jiac.2014.08.021
  • Peer Reviewed
• [Journal Article] A single 2 g oral dose of extended-release azithromycin for treatment of gonococcal urethritis. (2014)
  • Author(s): Yasuda M, Ito S, Kido A, Hamano K, Uchijima Y, Uwatoko N, Kusuyama H, Watanabe A, Miyamura R, Miyata K, Deguchi T.
  • Journal Title: Journal of Antimicrobial Chemotherapy Volume: 69 Issue: 11 Pages: 3116-3118
  • DOI: 10.1093/jac/dku221
  • Peer Reviewed
• [Journal Article] Clinical effectiveness and safety of tazobactam/piperacillin 4.5 g for the prevention of febrile infectious complication after prostate biopsy. (2014)
  • Author(s): Yasuda M, Nakane K, Yamada Y, Matsumoto M, Sho T, Matsumoto M, Kobayashi K, Shigemura K, Nakano Y, Tanaka K, Hamasuna R, Ishihara S, Arakawa S, Yamamoto S, Matsubara A, Fujisawa M, Deguchi T, Matsumoto T.
  • Journal Title: Journal of Infection and Chemotherapy Volume: 20 Issue: 10 Pages: 631-634
  • DOI: 10.1016/j.jiac.2014.06.011
  • Peer Reviewed
• [Presentation] 淋菌性尿道炎および非淋菌性尿道炎；AZM2g・単回 (2017)
  • Author(s): 安田 満
  • Organizer: 第91回日本感染症学会・第65回日本化学療法学会合同学会
  • Place of Presentation: 東京
  • Year and Date: 2017-04-06
• [Presentation] 尿道炎原因菌に対する抗菌活性;淋菌に対する抗菌活性 (2016)
  • Author(s): 安田 満
  • Organizer: 日本性感染症学会第29回学術大会
  • Place of Presentation: 岡山
  • Year and Date: 2016-12-03
• [Presentation] Clinical trials for Gonococcal Urethritis by Azithromycin 2g Single Dose (2016)
  • Author(s): 安田 満
  • Organizer: 19th IUSTI Asia-Pacific conference
  • Place of Presentation: 岡山
  • Year and Date: 2016-12-01
  • Int'l Joint Research
• [Presentation] 尿路性器感染症に関する臨床試験実施のためのガイドライン 第２版 (2016)
  • Author(s): 安田 満
  • Organizer: 第64回日本化学療法学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2016-06-10
• [Presentation] 性感染症ガイドライン (2016)
  • Author(s): 安田 満
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-23
• [Presentation] 三学会合同抗菌薬感受性サーベイランス報告 尿道炎 (2016)
  • Author(s): 安田 満
  • Organizer: 第90回日本感染症学会総会
  • Place of Presentation: 仙台
  • Year and Date: 2016-04-15
• [Presentation] 岐阜県における性感染症教育の取り組み (2016)
  • Author(s): 安田 満
  • Organizer: 第12回思春期性教育・性感染症研究会
  • Place of Presentation: 仙台
• [Presentation] 岐阜県における尿道炎・子宮頸管炎に関するガイドライン、診断・治療に関するアンケート調査 (2015)
  • Author(s): 安田 満、出口 隆、小林 博
  • Organizer: 第85回日本感染症学会西日本地方会学術集会，第58回日本感染症学会中日本地方会学術集会，第63回日本化学療法学会西日本支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2015-10-17
• [Presentation] 尿路性器感染症に関する臨床試験実施のためのガイドライン改訂委員会報告 (2015)
  • Author(s): 安田 満
  • Organizer: 第85回日本感染症学会西日本地方会学術集会，第58回日本感染症学会中日本地方会学術集会，第63回日本化学療法学会西日本支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2015-10-16
• [Presentation] JAID/JSC感染症治療ガイド2014｢尿路・性器感染症｣の改訂のポイント (2015)
  • Author(s): 安田 満
  • Organizer: 第85回日本感染症学会西日本地方会学術集会，第58回日本感染症学会中日本地方会学術集会，第63回日本化学療法学会西日本支部総会
  • Place of Presentation: 奈良
  • Year and Date: 2015-10-15
• [Presentation] 性感染症ガイドラインの正しい読み方 (2015)
  • Author(s): 安田 満
  • Organizer: 第80回日本泌尿器科学会東部総会
  • Place of Presentation: 東京
  • Year and Date: 2015-09-26
• [Presentation] 淋菌感染症治療の標準化に向けて (2014)
  • Author(s): 安田 満
  • Organizer: 日本性感染症学会第２７回学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-12-07
  • Invited
• [Presentation] 岐阜県における尿道炎・子宮頸管炎の診断・治療に関するアンケート調査 (2014)
  • Author(s): 安田 満、旗崎恭子、高井 学、河田 啓、 亀山紘司、高木公暁、堀江憲吾、清家健作、 出口 隆、小林 博
  • Organizer: 日本性感染症学会第２７回学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-12-07
• [Presentation] 2013年に男子淋菌性尿道炎患者より分離された淋菌の薬剤感受性報告 (2014)
  • Author(s): 安田 満、伊藤 晋、旗崎恭子、波多野紘一、成田晴紀 、 楊 睦正、米田尚生、 藤本佳則、前田真一 、 出口 隆
  • Organizer: 日本性感染症学会第２７回学術大会
  • Place of Presentation: 神戸
  • Year and Date: 2014-12-06
• [Presentation] Meet the Expert -専門医を目指して- 泌尿器感染症 (2014)
  • Author(s): 安田 満
  • Organizer: 第62回日本化学療法学会西日本支部総会、第57回日本感染症学会中日本地方会学術集会、第84回日本感染症学会西日本地方会学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2014-10-24
  • Invited