Establishment and regenerative research of urinary smooth muscle stem cells for urethral sphincter

• Project/Area Number: 26462443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Urology
• Research Institution: Okayama University
• Principal Investigator: Watanabe Toyohiko 岡山大学, 医歯薬学総合研究科, 准教授 (30432644)
• Co-Investigator(Kenkyū-buntansha): 渡部 昌実 岡山大学, 大学病院, 教授 (70444677) ; 植木 英雄 岡山大学, 医学部, 技術専門職員 (90537218)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 尿失禁 / 幹細胞 / 平滑筋再生 / 再生医学

Outline of Final Research Achievements

Urinary incontinence is associated with negative effects on a woman's social and physical well-being and the prevalence is increasing in Japan. In this study, we conducted a regenerative research for the establishment and application of urinary smooth muscle stem cells for the urethral sphincter. In the selected stem cells, expression of smooth muscle markers was confirmed by immunohistochemistry.