the functional and morfological evaluation of extracellular matrix in urethral tissue
| Project/Area Number |
26462446
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Oita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
吉岡 秀克 大分大学, 医学部, 教授 (00222430)
|
|---|
| Research Collaborator |
Shinohara Mayuka
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | コラーゲンⅩⅨ / Leak point pressure / 外尿道括約筋 / 尿禁制 / 尿道 / 細胞外マトリクス / 加齢 / サイトカイン / 腹圧性尿失禁 |
|---|
| Outline of Final Research Achievements |
We explored whether CollagenⅩⅨ, one of FACIT collagens, effects on the rhabdosphincter. We made CollageⅩⅨ knockout female mice and used 129/wild type female mice as control. We measured Leak Point Pressure as the functional assessment, and mean area of urethral lumen and urethal circumference of as morphological evaluations at 4week-old.
In resuls, there were no significant difference between two groups in functional and morphogical enaluations. So, CollagenⅩⅨ doesn’t involve with function of rhabdosphincter.
|
Report
(4 results)
Research Products
(19 results)
-
-
-
-
-
[Journal Article] Dual targeting of heat shock proteins 90 and 70 promotes cell death and enhances the anticancer effect of chemotherapeutic agents in bladder cancer.2014
Author(s)
Ma L, Sato F, Sato R, Matsubara T, Hirai K, Yamasaki M, Shin T, Shimada T, Nomura T, Mori K, Sumino Y, Mimata H.
-
Journal Title
Oncol Rep
Volume: 31
Issue: 6
Pages: 2482-92
DOI
Related Report
Peer Reviewed
-
[Presentation] TNF-αはヒト外尿道括約筋細胞の分化を抑制する2016
Author(s)
篠原 麻由香(大分大学 腎泌尿器外科), 住野 泰弘, 花田 麻里, 秋田 泰之, 秦 聡孝, 佐藤 文憲, 橋本 有弘, 三股 浩光
Organizer
日本排尿機能学会
Place of Presentation
東京国際フォーラム東京都、千代田区
Year and Date
2016-12-06
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
