| Project/Area Number |
26462450
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
安藤 亮介 名古屋市立大学, 大学院医学研究科, 助教 (30381867)
戸澤 啓一 名古屋市立大学, 大学院医学研究科, 准教授 (40264733)
安井 孝周 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
岡田 淳志 名古屋市立大学, 大学院医学研究科, 講師 (70444966)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 尿路結石 / ゲノムワイド関連解析 / マルチプレックス解析 / 炎症 / マクロファージ / リスク因子 / 結石消失 / ケモカイン / サイトカイン / SNP / ゲノムワイド解析 |
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| Outline of Final Research Achievements |
We have conducted large-scale screening focusing on single nucleotide polymorphisms (SNPs), identified multiple urinary calculi related regions on the genome, and reported the association with onset risk. In this study, we performed (1) haplotype analysis of the related genes based on the results of genome-wide association analysis, and (2) multiplex analysis for kidney stone-related urinary markers between kidney stones and healthy subjects.
As a result, we identified 5q 35.3, 7 p 14. 3 and 13 q 14. 1 areas related to stone formation and found that the odds ratio increased with the number of risk allele . In addition, urinary IL-1a and IL-4 were identified as the factors to discriminate normal subjects from calculus patients (especially initial stone formers) by multiplex analysis of urinary inflammation-related factors.
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