The role of TSP-1 in the pathogenesis of benign prostatic hyperplasia via inflammation.
| Project/Area Number |
26462451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
SASAKI Shoichi 名古屋市立大学, 大学院医学研究科, 研究員 (50225869)
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| Co-Investigator(Kenkyū-buntansha) |
濱川 隆 名古屋市立大学, 大学院医学研究科, 助教 (40595394)
窪田 泰江 名古屋市立大学, 大学院医学研究科, 講師 (00381830)
小島 祥敬 福島県立医科大学, 医学部, 教授 (60305539)
郡 健二郎 名古屋市立大学, その他部局等, 学長 (30122047)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 前立腺肥大症 / TSP-1 / 炎症 / 間質肥大 |
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| Outline of Final Research Achievements |
Previously, we reported that interleukin-18 (IL-18) may promote stromal hyperplasia in the prostate by inducing production of thrombospondin-1 (TSP-1) using BPH rat model.
First, To clarify the role of TSP-1 in the development of BPH, we administered the IL-18-binding protein (IL-18BP), an inhibitor of IL-18, in the peritoneum of the model rats. The administration of IL-18BP affected the dose-dependent decreases in TSP-1 mRNA expression levels. The Masson trichrome stain of rat prostate showed that the expression levels of the collagen fibrils were likely decreased by the administration of IL-18BP in the BPH tissues. Next study, we aimed to determine the expression levels of TSP-1 in human prostate tissue and assess the correlation of these expressions and clinical parameters. As a result, TSP-1 was positively correlated with prostate volume and the increase in prostate volume per day.
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Report
(4 results)
Research Products
(13 results)
